公开(公告)号：US06593347B2

公开(公告)日：2003-07-15

申请号：US09938560

申请日：2001-08-27

申请人： Upul K. Bandarage ,  Qing Dong ,  Xinqin Fang ,  David S. Garvey ,  Gregory J. Mercer ,  Stewart K. Richardson ,  Joseph D. Schroeder ,  Tiansheng Wang

发明人： Upul K. Bandarage ,  Qing Dong ,  Xinqin Fang ,  David S. Garvey ,  Gregory J. Mercer ,  Stewart K. Richardson ,  Joseph D. Schroeder ,  Tiansheng Wang

IPC分类号： A61K31445

CPC分类号： C07D207/08 ,  A61K45/06 ,  C07C381/00 ,  C07C2601/14 ,  C07D209/28 ,  C07D211/22 ,  C07D211/26 ,  C07D211/54 ,  C07D211/62 ,  C07D239/47 ,  C07D241/06 ,  C07D263/20 ,  C07D295/088 ,  C07D295/185 ,  C07D295/192 ,  C07D317/32 ,  C07F9/4006 ,  C07F9/4075

摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

公开(公告)号：US06297260B1

公开(公告)日：2001-10-02

申请号：US09429019

申请日：1999-10-29

申请人： Upul K. Bandarage ,  Qing Dong ,  Xinqin Fang ,  David S. Garvey ,  Gregory J. Mercer ,  Stewart K. Richardson ,  Joseph D. Schroeder ,  Tiansheng Wang

发明人： Upul K. Bandarage ,  Qing Dong ,  Xinqin Fang ,  David S. Garvey ,  Gregory J. Mercer ,  Stewart K. Richardson ,  Joseph D. Schroeder ,  Tiansheng Wang

IPC分类号： A61K31445

CPC分类号： C07D207/08 ,  A61K45/06 ,  C07C381/00 ,  C07C2601/14 ,  C07D209/28 ,  C07D211/22 ,  C07D211/26 ,  C07D211/54 ,  C07D211/62 ,  C07D239/47 ,  C07D241/06 ,  C07D263/20 ,  C07D295/088 ,  C07D295/185 ,  C07D295/192 ,  C07D317/32 ,  C07F9/4006 ,  C07F9/4075

摘要： The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的非甾族化合物抗炎化合物，以及包含至少一种亚硝化和/或亚硝基化的非甾族化合物抗炎化合物的新组合物，以及任选的至少一种捐赠，转移或释放一氧化氮的化合物，提高内源性水平 的内皮衍生的松弛因子，刺激一氧化氮的内源性合成，或是一氧化氮合酶的底物。 本发明还提供了治疗，预防和/或减轻炎症，疼痛和发烧的方法; 减少或逆转使用非甾体抗炎药物引起的胃肠道，肾脏和其他毒性; 治疗和/或预防胃肠道疾病; 治疗炎性疾病状态和障碍; 以及治疗和/或预防眼科疾病或病症。