公开(公告)号：US08323683B2

公开(公告)日：2012-12-04

申请号：US11131561

申请日：2005-05-18

申请人： Seema Mody ,  Gregory Koll

发明人： Seema Mody ,  Gregory Koll

IPC分类号： A24B15/16 ,  A24B15/00 ,  A23G4/00 ,  A23G4/08

CPC分类号： A61K9/0058

摘要： A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.

摘要翻译： 一种口香糖，其包含至少一种具有芯的活性药物成分（API），其上施用至少一个内部聚合物膜涂层，此后施加至少一个外部硬涂层。 优选的API是尼古丁。 调味剂可以并入到核心，至少一个内部聚合物膜涂层和/或至少一个外部硬质涂层中。 形成的牙龈表现出持久的调味剂效果，并导致涂层中的调味剂与核心中的调味剂的统称，从而（a）避免了化学或药物不相容性的问题 涂层中的核心和调味剂中的API和（b）实现API和非活性赋形剂的释放的增加的控制。

公开(公告)号：US20070269386A1

公开(公告)日：2007-11-22

申请号：US11444787

申请日：2006-06-01

申请人： Per Steen ,  Darek Dymitrowicz ,  Andreas Hugerth ,  Asa Waltermo ,  Magnus Palsson ,  Roland Olsson ,  Fredrik Nicklasson ,  Anette Schluter ,  Kristina Thyresson ,  Seema K. Mody ,  Bengt Bosson ,  Katarina Lindell ,  Gregory Koll

发明人： Per Steen ,  Darek Dymitrowicz ,  Andreas Hugerth ,  Asa Waltermo ,  Magnus Palsson ,  Roland Olsson ,  Fredrik Nicklasson ,  Anette Schluter ,  Kristina Thyresson ,  Seema K. Mody ,  Bengt Bosson ,  Katarina Lindell ,  Gregory Koll

IPC分类号： A61K31/4439 ,  A61K9/68

CPC分类号： A61K9/0056 ,  A61K9/0058 ,  A61K9/006 ,  A61K9/12 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/7007 ,  A61K31/465

摘要： A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least trometamol. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of the oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.

摘要翻译： 一种药物口服制剂，其用于通过口腔内经粘膜摄取将任何形式的尼古丁递送至受试者，其包含任何形式的尼古丁，其中所述口服制剂至少使用氨丁三醇缓冲。 还考虑了以任何形式口服输送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法，口服制剂用于获得尼古丁的经粘膜摄取的方法 在对象的口腔中，以及使用尼古丁来制备用于治疗选自烟草或尼古丁依赖性疾病，阿尔茨海默氏病，克罗恩病，帕金森病，图雷特综合征，溃疡性结肠炎的口服制剂 和戒烟后重量控制。

公开(公告)号：US20060275344A1

公开(公告)日：2006-12-07

申请号：US11131561

申请日：2005-05-18

申请人： Seema Mody ,  Gregory Koll

发明人： Seema Mody ,  Gregory Koll

IPC分类号： A61K47/00

CPC分类号： A61K9/0058

摘要： A chewing gum comprising at least one active pharmaceutical ingredient (API) with a core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent(s) and result in the domination of flavoring agents in the coating(s) over flavoring agent(s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent(s) in the coating(s) and (b) achieving an increased control of the release of the API and of non-active excipients.

摘要翻译： 一种口香糖，其包含至少一种具有芯的活性药物成分（API），其上施用至少一个内部聚合物膜涂层，此后施加至少一个外部硬涂层。 优选的API是尼古丁。 调味剂可以并入到核心，至少一个内部聚合物膜涂层和/或至少一个外部硬质涂层中。 形成的牙龈表现出持久的调味剂效果，并导致涂层中的调味剂与核心中的调味剂的统称，从而（a）避免了化学或药物不相容性的问题 涂层中的核心和调味剂中的API和（b）实现API和非活性赋形剂的释放的增加的控制。