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公开(公告)号:US20120326025A1
公开(公告)日:2012-12-27
申请号:US13575903
申请日:2011-01-28
申请人: Klaus Weinberger , Hans-Peter Deigner , Emeka Ignatius Igwe , David Enot , Guido Dallmann , Helmut Klocker
发明人: Klaus Weinberger , Hans-Peter Deigner , Emeka Ignatius Igwe , David Enot , Guido Dallmann , Helmut Klocker
IPC分类号: H01J49/26
CPC分类号: G01N33/57434 , G01N2800/54
摘要: The invention discloses the use of at least one substance selected from the group consisting of Phosphatidylcholine with diacyl residue sum C24:0 (PC aa C24:0); Phosphatidylcholine with diacyl residue sum C40:3 (PC ae C40:3); Phosphatidylcholine with diacyl residue sum C40:4 (PC ae C40:4); Lysophosphatidylcholine with acyl residue sum C26:0 (lysoPC a C26:0); Lysophosphatidylcholine with acyl residue sum C6:0 (lysoPC a C6:0); 13(S)-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE); 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12S-HETE); 15(S)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15S-HETE); Leukotriene B4 (LTB4); Prostaglandin E2 (PGE2); Prostaglandin D2 (PGD2); 7α-Hydroxycholesterol (7aOHC); 7-Ketocholesterol (7KC); 5β,6β-Epoxycholesterol (5b,6b,EPC); 5g302,6g302-Epoxycholesterol (5a,6a,EPC); and 4β-Hydroxycholesterol (4BOHC); for prognosticating relapse of a prostate cancer (PCa) in a sample of a body fluid or a tissue sample of a PCa patient.
摘要翻译: 本发明公开了使用选自由二酰基残基和C24:0(PCaa C24:0)组成的组的至少一种物质; 具有二酰基残基总数C40:3的磷脂酰胆碱(PC ae C40:3); 具有二酰基残基的磷脂酰胆碱总数C40:4(PC ae C40:4); 酰基残基总数为C26:0的溶血磷脂酰胆碱(lysoPC a C26:0); 具有酰基残基的溶血磷脂酰胆碱和C6:0(溶血糖素a C6:0); 13(S) - 羟基-9Z,11E-十八碳二烯酸(13S-HODE); 12(S) - 羟基-5Z,8Z,10E,14Z-二十碳四烯酸(12S-HETE); 15(S) - 羟基-5Z,8Z,11Z,13E-二十碳四烯酸(15S-HETE); 白三烯B4(LTB4); 前列腺素E2(PGE2); 前列腺素D2(PGD2); 7α-羟基胆固醇(7aOHC); 7-酮胆固醇(7KC); 5&bgr;,6&bgr; - 环氧胆固醇(5b,6b,EPC); 5g302,6g302-环氧胆固醇(5a,6a,EPC); 和4&bgr; - 羟基胆固醇(4BOHC); 用于预测PCa患者体液或组织样品中前列腺癌(PCa)的复发。