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    Quinazolinone derivatives as ALDH-2 inhibitors
    2.
    发明授权
    Quinazolinone derivatives as ALDH-2 inhibitors 有权
    喹唑啉酮衍生物作为ALDH-2抑制剂

    公开(公告)号：US07951813B2

    公开(公告)日：2011-05-31

    申请号：US12062431

    申请日：2008-04-03

    申请人： Matthew Abelman ,  Michael Organ ,  Jeff Zablocki ,  Wing Ming Keung ,  Guoxin Tao

    发明人： Matthew Abelman ,  Michael Organ ,  Jeff Zablocki ,  Wing Ming Keung ,  Guoxin Tao

    IPC分类号： A61K31/517

    CPC分类号： C07D413/12 ,  C07D239/88

    摘要： Disclosed are novel quinazolinone derivatives of formula: wherein: R1 is optionally substituted phenyl or optionally substituted heteroaryl; R2 is 3-hydroxy, 4-hydroxy, 3-NHR4 or 4-NHR4, in which R4 is hydrogen, —C(O)R5, —C(O)NHR6, or —SO2R6; in which R5 is optionally substituted lower alkyl or optionally substituted lower alkoxy; and R6 is optionally substituted lower alkyl; R3 is hydrogen, lower alkyl, lower alkoxy, or halo; V is oxygen, sulfur, or —NH—; and W is lower alkylene of 1-3 carbon atoms, which are useful as ALDH-2 inhibitors for treating mammals for various disease states, such as treatment for cocaine dependency and alcohol dependency.

    摘要翻译： 公开了下式的新的喹唑啉酮衍生物：其中：R 1是任选取代的苯基或任选取代的杂芳基; R2是3-羟基，4-羟基，3-NHR4或4-NHR4，其中R4是氢，-C（O）R5，-C（O）NHR6或-SO2R6; 其中R 5是任选取代的低级烷基或任选取代的低级烷氧基; 并且R 6是任选取代的低级烷基; R3是氢，低级烷基，低级烷氧基或卤素; V是氧，硫或-NH-; 并且W是1-3个碳原子的低级亚烷基，其可用作用于治疗各种疾病状态的哺乳动物的ALDH-2抑制剂，例如对可卡因依赖性和醇依赖性的治疗。