公开(公告)号：US20060147498A1

公开(公告)日：2006-07-06

申请号：US10543856

申请日：2004-01-23

Applicant: Ingemar Jonsson ,  Hans Lidgard ,  Gustaf Forshell

Inventor： Ingemar Jonsson ,  Hans Lidgard ,  Gustaf Forshell

IPC: A61K9/00 ,  A61K9/28

CPC classification number: A61K9/0058 ,  A61K9/006 ,  A61K9/009 ,  A61K9/205 ,  A61K9/2054

Abstract: The invention refers to a composition material that is intended for rapid transmucosal delivery in the mouth of a biologically active substance when in contact with saliva. The composition material comprises at least one ionic carbohydrate, having at least one biologically active substance ionically bound thereto, and at least one wetable non-soluble polymeric carbohydrate. The invention also refers to a method of preparing the composition material, which comprises the steps of: (a) providing a mixture of the at least one biologically active substance and at least one ionic carbohydrate in a solvent having a permissive pH for ionic bonding of the at least one biologically active substance to the at least one ionic carbohydrate; (b) mixing the mixture in the solvent for a period that is sufficient for allowing the ionic bonding to take place; and (c) recovering the mixture from the solvent.

Abstract translation: 本发明涉及一种用于在与唾液接触时在生物活性物质的口中快速透粘膜递送的组合物材料。 所述组合物材料包含至少一种具有离子键合的至少一种生物活性物质的至少一种离子性碳水化合物和至少一种可润湿的非可溶性聚合碳水化合物。 本发明还涉及一种制备组合物材料的方法，其包括以下步骤：（a）在溶剂中提供至少一种生物活性物质和至少一种离子型碳水化合物的混合物，所述溶剂具有用于离子键合的允许pH 所述至少一种生物活性物质至少一种离子型碳水化合物; （b）将混合物在溶剂中混合足以使离子键发生的时间; 和（c）从溶剂中回收混合物。