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公开(公告)号：US10822339B2
公开(公告)日：2020-11-03
申请号：US16073027
申请日：2017-01-25
发明人： Jianming Yin , Yubin Lv , Bangliang Li
IPC分类号： C07D487/04 , A61P37/06 , A61P19/02 , A61K31/519
摘要： The present invention relates to a pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and/or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative of the invention is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like. The pyrrolopyrimidine five-membered azacyclic derivative has the general formula of formula I
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公开(公告)号：US20190040068A1
公开(公告)日：2019-02-07
申请号：US16073027
申请日：2017-01-25
发明人： Jianming YIN , Yubin LV , Bangliang LI
IPC分类号： C07D487/04 , A61P19/02 , A61P37/06
摘要： A pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase (Janus kinase) inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and/or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like.
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公开(公告)号：US10065931B2
公开(公告)日：2018-09-04
申请号：US15571582
申请日：2016-05-03
发明人： Yubin Lv , Jianming Yin , Xuehui Huang , Bangliang Li
IPC分类号： C07D239/94 , A61P35/00
摘要： Disclosed are crystal forms K, E, F and G of the dimaleate of the compound as shown in formula I, and preparation methods and uses thereof. The crystal forms K, E, F and G have superior storage stability and solubility, so that they are more suitable for being used as the drug substance for drug product preparations.
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4.发明申请公开(公告)号：US20180312472A1
公开(公告)日：2018-11-01
申请号：US16017084
申请日：2018-06-25
发明人： Yubin LV , Jianming YIN , Xuehui HUANG , Bangliang LI
IPC分类号： C07D239/94 , A61P35/00 , A61K31/517
CPC分类号： C07D239/94 , A61K31/517 , A61P35/00 , C07B2200/13
摘要： Disclosed are crystal forms K, E, F and G of the dimaleate of the compound as shown in formula I, and preparation methods and uses thereof. The crystal forms K, E, F and G have superior storage stability and solubility, so that they are more suitable for being used as the drug substance for drug product preparations.
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