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1.发明申请RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF 有权RNA干扰抑制神经细胞增生性疾病及其使用方法公开(公告)号：US20110111491A1
公开(公告)日：2011-05-12
申请号：US12774019
申请日：2010-05-05
Applicant: Beverly L. Davidson , Henry Paulson , Ryan Boudreau , Scott Harper , Haibin Xia , Qinwen Mao
Inventor： Beverly L. Davidson , Henry Paulson , Ryan Boudreau , Scott Harper , Haibin Xia , Qinwen Mao
IPC: C07H21/02 , C12N15/85 , C12N5/10 , C12N15/86 , C12N15/861
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Abstract translation: 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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公开(公告)号：US20060009408A1
公开(公告)日：2006-01-12
申请号：US11047429
申请日：2005-01-31
Applicant: Beverly Davidson , Haibin Xia , Qinwen Mao
Inventor： Beverly Davidson , Haibin Xia , Qinwen Mao
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
Abstract translation: 本发明涉及编码针对目标基因的小干扰RNA分子（siRNA）的病毒载体，以及使用这些病毒载体的方法。
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3.发明申请RNA interference suppresion of neurodegenerative diseases and methods of use thereof 审中-公开RNA干扰抑制神经变性疾病及其使用方法公开(公告)号：US20050042646A1
公开(公告)日：2005-02-24
申请号：US10859751
申请日：2004-06-02
Applicant: Beverly Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau
Inventor： Beverly Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau
IPC: A61K38/00 , A61K48/00 , C07H21/02 , C12N5/22 , C12N15/113 , C12N15/861 , C12Q1/68
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Abstract translation: 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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4.发明授权RNA interference suppresion of neurodegenerative diseases and methods of use thereof 有权RNA干扰抑制神经变性疾病及其使用方法公开(公告)号：US08524879B2
公开(公告)日：2013-09-03
申请号：US12774019
申请日：2010-05-05
Applicant: Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan L. Boudreau , Scott Harper
Inventor： Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan L. Boudreau , Scott Harper
IPC: C07H21/04
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Abstract translation: 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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5.发明授权RNA interference suppression of neurodegenerative diseases and methods of use thereof 有权神经变性疾病的RNA干扰抑制及其使用方法公开(公告)号：US08481710B2
公开(公告)日：2013-07-09
申请号：US12963793
申请日：2010-12-09
Applicant: Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau , Scott Harper
Inventor： Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau , Scott Harper
IPC: C07H21/04
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2310/531 , C12N2750/14143 , C12N2799/021 , C12N2799/022 , C12N2799/025 , Y02A50/465
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Abstract translation: 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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Patent Agency Ranking
公开(公告)号：US20100190243A1
公开(公告)日：2010-07-29
申请号：US12546418
申请日：2009-08-24
Applicant: Beverly L. Davidson , Haibin Xia , Qinwen Mao
Inventor： Beverly L. Davidson , Haibin Xia , Qinwen Mao
IPC: C12N15/74
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
Abstract translation: 本发明涉及编码针对目标基因的小干扰RNA分子（siRNA）的病毒载体，以及使用这些病毒载体的方法。
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公开(公告)号：US20100144026A1
公开(公告)日：2010-06-10
申请号：US12455018
申请日：2009-05-27
Applicant: Beverly L. Davidson , Haibin Xia , Qinwen Mao
Inventor： Beverly L. Davidson , Haibin Xia , Qinwen Mao
IPC: C12N15/74
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2799/021 , C12N2799/022 , Y02A50/465
Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
Abstract translation: 本发明涉及编码针对目标基因的小干扰RNA分子（siRNA）的病毒载体，以及使用这些病毒载体的方法。
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公开(公告)号：US20050112640A1
公开(公告)日：2005-05-26
申请号：US10952486
申请日：2004-09-28
Applicant: Beverly Davidson , Qinwen Mao , Haibin Xia
Inventor： Beverly Davidson , Qinwen Mao , Haibin Xia
CPC classification number: C07K14/005 , C07K2319/02 , C07K2319/10 , C12N15/62 , C12N2740/16322
Abstract: The present invention provides polynucleotides and expression vectors containing a sequence encoding a soluble lysosomal enzyme and a sequence encoding Tat protein transduction domain (PTD), and the corresponding polypeptides. The present demonstrates the utility of these protein fusions in altering the bioavailability of proteins for use in treating genetic diseases or acquired diseases. The invention further provides cell expression systems, and methods of treating a genetic disease or cancer in a mammal using the polynucleotides, polypeptides, or expression system of the present invention.
Abstract translation: 本发明提供了含有编码可溶性溶酶体酶的序列和编码Tat蛋白转导结构域（PTD）的序列的多核苷酸和表达载体以及相应的多肽。 本发明证明了这些蛋白质融合体在改变用于治疗遗传疾病或获得性疾病的蛋白质的生物利用度方面的效用。 本发明还使用本发明的多核苷酸，多肽或表达系统进一步提供细胞表达系统和治疗哺乳动物遗传疾病或癌症的方法。
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公开(公告)号：US20050106731A1
公开(公告)日：2005-05-19
申请号：US10212322
申请日：2002-08-05
Applicant: Beverly Davidson , Haibin Xia , Qinwen Mao
Inventor： Beverly Davidson , Haibin Xia , Qinwen Mao
IPC: A61K38/00 , A61K48/00 , C07H21/02 , C12N5/22 , C12N15/113 , C12N15/861 , C12N15/86
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2799/021 , C12N2799/022 , Y02A50/465
Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
Abstract translation: 本发明涉及编码针对目标基因的小干扰RNA分子（siRNA）的病毒载体，以及使用这些病毒载体的方法。
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10.发明申请RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF 有权RNA干扰抑制神经损伤性疾病及其使用方法公开(公告)号：US20110212520A1
公开(公告)日：2011-09-01
申请号：US12963793
申请日：2010-12-09
Applicant: Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau , Scott Harper
Inventor： Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan Boudreau , Scott Harper
CPC classification number: C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2310/531 , C12N2750/14143 , C12N2799/021 , C12N2799/022 , C12N2799/025 , Y02A50/465
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Abstract translation: 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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