公开(公告)号：US20050075359A1

公开(公告)日：2005-04-07

申请号：US10665528

申请日：2003-09-22

申请人： Rikako Kono ,  Shuntarou Kohnomi ,  Hajime Aihara ,  Toshihiro Hosaka ,  Toshihiko Kashiwagi

发明人： Rikako Kono ,  Shuntarou Kohnomi ,  Hajime Aihara ,  Toshihiro Hosaka ,  Toshihiko Kashiwagi

IPC分类号： A61K31/33 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/18 ,  A61K31/40 ,  A61K31/42 ,  A61K31/425

CPC分类号： A61K31/33 ,  A61K31/415

摘要： There is disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein R1 is aminosulfonyl, alkylsulfonyl, etc., R2 is hydrogen or halogen, R3 and R4 are hydrogen, halogen, alkyl or alkoxy, Ring A is benzene, pyridine, etc., and Ring Q is pyrazol, isoxazol, etc., and Ring Q and Ring A may be combined to each other to form a fused ring of the formula: where X is S or O, R5 is halogen, alkyl, etc., and R3 and R4 are the same as mentioned above, or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 公开了一种大电导钙活化的K通道开放剂，其包含式（I）化合物：其中R 1是氨基磺酰基，烷基磺酰基等，R 2是氢或卤素，R 3和R 4，是氢，卤素，烷基或烷氧基，环A是苯，吡啶等，环Q是吡唑，异恶唑等，并且环Q和环A可以相互结合形成稠环 其中X是S或O，R 5是卤素，烷基等，R 3和R 4与上述相同，或其药学上可接受的盐作为活性成分 。