公开(公告)号：US20110119781A1

公开(公告)日：2011-05-19

申请号：US13054111

申请日：2009-07-08

申请人： Birgit Bramlage ,  Markus Hossbach ,  Pamela Tan ,  Hans-Peter Vamlocher

发明人： Birgit Bramlage ,  Markus Hossbach ,  Pamela Tan ,  Hans-Peter Vamlocher

IPC分类号： A01K67/027 ,  C07H21/02 ,  C12N5/10

CPC分类号： C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a TGF-beta receptor type I gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length and which is substantially complementary to at least a part of a TGF-beta receptor type I gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a TGF-beta receptor type I gene using said pharmaceutical composition; and methods for inhibiting the expression of a TGF-beta receptor type I gene in a cell.

摘要翻译： 本发明涉及用于抑制TGF-β受体I型基因表达的双链核糖核酸（dsRNA），其包含具有长度小于30个核苷酸的核苷酸序列的反义链，并且其与 至少一部分TGF-β受体I型基因。 本发明还涉及包含dsRNA或核酸分子的药物组合物或其编码与其药学上可接受的载体的载体; 使用所述药物组合物治疗由TGF-β受体I型基因表达引起的疾病的方法; 以及用于抑制细胞中TGF-β受体I型基因表达的方法。