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1.发明申请公开(公告)号：US20170367683A1
公开(公告)日：2017-12-28
申请号：US15090357
申请日：2016-04-04
Applicant: Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
Inventor： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
CPC classification number: A61B8/485 , A61B8/5223 , G01S7/52022 , G01S7/52038 , G01S7/52042 , G01S7/52071 , G01S7/6263
Abstract: Methods and apparatus measuring tissue nonlinear shear wave property are disclosed. When tissue shear responses are different to ultrasound radiation forces generated by pulses having different shapes, its nonlinear effect can be used to estimate tissue property at single location without measurements of group velocities or phase velocities. Ultrasound radiation force using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location in a tissue region. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties. The property includes nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions in the tissue region for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity. A difference between certain aspects of this disclosure and the prior art of ultrasound elastography is the utilization of nonlinear responses of the tissue shear property.
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公开(公告)号：US10327739B2
公开(公告)日：2019-06-25
申请号：US15090357
申请日：2016-04-04
Applicant: Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
Inventor： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
Abstract: Ultrasound radiation using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties including nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity.
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