公开(公告)号：US20100266501A1

公开(公告)日：2010-10-21

申请号：US12312093

申请日：2007-11-06

申请人： Markus Meyer ,  Martin M. LeWinter ,  Harold L. Dauerman ,  Stephen P. Bell

发明人： Markus Meyer ,  Martin M. LeWinter ,  Harold L. Dauerman ,  Stephen P. Bell

IPC分类号： A61K49/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/12 ,  A61P39/06

CPC分类号： A61K49/0447 ,  A61K31/195 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates in some aspects to compositions that include a contrast agent and an antioxidant compound and the use of such compositions to prevent (e.g., reduce) organ damage in a subject. In some aspects, the invention relates to compositions that include N— acetylcysteine (NAC) and a contrast agent and the use of such compositions for preventing organ damage in a subject. Methods of preventing organ damage may include the simultaneous administration of a composition of the invention, such that a contrast agent and an antioxidant compound or a contrast agent and NAC are administered intravascularly to a subject. Examples of organ damage that may be treated with compositions and methods of the invention include contrast-induced and non-contrast induced organ damage associated with myocardial ischemia, myocardial infarction, reperfusion damage, nephropathy, etc. The invention, in some aspects, also includes kits that may include a contrast agent and NAC and/or an antioxidant compound.

摘要翻译： 本发明在一些方面涉及包括造影剂和抗氧化剂化合物的组合物，以及这些组合物用于预防（例如减少）受试者器官损害的用途。 在一些方面，本发明涉及包含N-乙酰半胱氨酸（NAC）和造影剂的组合物，以及这些组合物用于预防受试者器官损伤的用途。 预防器官损害的方法可以包括同时施用本发明的组合物，使得造影剂和抗氧化剂化合物或造影剂和NAC被血管内施用于受试者。 可以用本发明的组合物和方法治疗的器官损伤的实例包括与心肌缺血，心肌梗塞，再灌注损伤，肾病等相关的造影诱导和非造影诱导的器官损伤。在一些方面，本发明还包括 可以包括造影剂和NAC和/或抗氧化剂化合物的试剂盒。