公开(公告)号：US20180298099A1

公开(公告)日：2018-10-18

申请号：US15759095

申请日：2016-09-16

申请人： Harry C. Ledebur, JR.

发明人： Harry C. Ledebur, JR.

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P17/00

摘要： The present invention provides methods and compositions for treating immune mediated adverse drug reactions using anti-αβ TCR antibodies and fragments thereof. The adverse drug reactions treated according to the invention include severe cutaneous adverse reactions, idiosyncratic liver injury, and idiopathic drug-induced liver disease. The invention also provides methods and compositions for treating conditions such as epidermolysis bullosa, pemphigus vulgaris, cutaneous T cell lymphoma, and Goodpasture syndrome where T cells play a significant role. Anti-α TCR antibodies used in the treatment methods of the invention include T10B9, MEDI-500 and TOL101.

公开(公告)号：US06416998B1

公开(公告)日：2002-07-09

申请号：US08479913

申请日：1995-06-07

申请人： Bert W. O'Malley ,  Ming-Jer Tsai ,  Harry C. Ledebur, Jr. ,  Joseph D. Kittle, Jr.

发明人： Bert W. O'Malley ,  Ming-Jer Tsai ,  Harry C. Ledebur, Jr. ,  Joseph D. Kittle, Jr.

IPC分类号： C12N1512

CPC分类号： C12N15/8237 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/721 ,  C12N15/63 ,  C12N15/8238 ,  G01N33/566 ,  G01N33/743 ,  G01N2333/723 ,  G01N2500/10

摘要： The present invention provides mutated proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

摘要翻译： 本发明提供类固醇激素受体的突变蛋白。 这些突变的蛋白质可用作基因药物。 特别地，这些突变的蛋白质可用于调节基因治疗中基因的表达。 此外，本发明提供编码所需突变的类固醇激素受体蛋白质的质粒以及用这些质粒转染的细胞。