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    Immunostimulatory oligonucleotide that induces interferon alpha
    2.
    发明授权
    Immunostimulatory oligonucleotide that induces interferon alpha 有权
    诱导干扰素α的免疫刺激性寡核苷酸

    公开(公告)号：US07718623B2

    公开(公告)日：2010-05-18

    申请号：US10590761

    申请日：2005-02-25

    申请人： Harukazu Kitagawa ,  Sumiko Iho ,  Takasumi Matsuki ,  Saburo Yamamoto

    发明人： Harukazu Kitagawa ,  Sumiko Iho ,  Takasumi Matsuki ,  Saburo Yamamoto

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  A61K39/38

    CPC分类号： A61K45/06 ,  A61K39/39 ,  A61K2039/55561

    摘要： An immunostimulatory oligonucleotide that is represented by the general formula 5′-Gm-GACGATCGTC-Gn-3′ or 5′-Gm-CACGATCGTG-Gn-3′ (in the formula, m and n are each independently an integer from 1 to 9 and m+n=10) and that comprises any of the following base sequences: GGACGATCGTCGGGGGGGGG (SEQ. ID. NO.: 1), GGGACGATCGTCGGGGGGGG (SEQ. ID. NO.: 2), GGGGACGATCGTCGGGGGGG (SEQ. ID. NO.: 3), GGGGGGGACGATCGTCGGGG (SEQ ID NO: 4), GGGGGGGGACGATCGTCGGG (SEQ. ID. NO.: 5), GGGGGGGGGACGATCGTCGG (SEQ. ID. NO.: 6), GGGGGGGGGGACGATCGTCG (SEQ. ID. NO.: 7), and GGGGGGGGGCACGATCGTGG (SEQ. ID. NO.: 8).

    摘要翻译： 由通式5'-Gm-GACGATCGTC-Gn-3'或5'-Gm-CACGATCGTG-Gn-3'表示的免疫刺激性寡核苷酸（式中，m和n各自独立地为1〜9的整数 和m + n = 10），并且其包含以下任何碱基序列：GGACGATCGTCGGGGGGGGGG（SEQ ID NO：1），GGGACGATCGTCGGGGGGGGG（SEQ ID NO：2），GGGGACGATCGTCGGGGGGGG（SEQ ID NO： 3），GGGGGGGACGATCGTCGGGG（SEQ ID NO：4），GGGGGGGGGACGATCGTCGGG（SEQ.ID.NO:5），GGGGGGGGGGACGATCGTCGG（SEQ.ID.NO:6），GGGGGGGGGGGACGATCGTCG（SEQ.ID.NO:7）和GGGGGGGGGGCACGATCGTGG （SEQ ID NO：8）。