公开(公告)号：US20120302636A1

公开(公告)日：2012-11-29

申请号：US13328787

申请日：2011-12-16

申请人： Harutoshi KON ,  Yoshiro Masuda ,  Hiromitsu Watanabe

发明人： Harutoshi KON ,  Yoshiro Masuda ,  Hiromitsu Watanabe

IPC分类号： A61K31/216 ,  A61P9/00 ,  A61P9/12 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00

CPC分类号： A61K31/216 ,  A61K31/222

摘要： Provided is a method of treating or preventing a disorder in a subject comprising administering twice per day a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrate thereof, to a subject that has or is at risk of having a disorder selected from the group consisting of hyperlipidemia, arteriosclerosis, coronary artery diseases, metabolic syndrome, obesity, diabetes, prediabetes, and hypertension, whereupon the disorder is treated or prevented in the subject. The method optionally comprises administering a therapeutically effective amount of the compound of formula (I), or a pharmaceutically acceptable salt, solvate, or hydrate thereof, to the subject, in which the therapeutically effective amount is increased once or twice during the course of administration.

摘要翻译： 本发明提供了治疗或预防受试者疾病的方法，其包括每天给予治疗有效量的式（I）化合物或其药学上可接受的盐，溶剂合物或水合物给具有或处于 具有选自高脂血症，动脉硬化，冠状动脉疾病，代谢综合征，肥胖症，糖尿病，糖尿病前期和高血压的疾病的风险，因此在受试者中治疗或预防疾病。 该方法任选地包括给予受试者治疗有效量的式（I）化合物或其药学上可接受的盐，溶剂化物或水合物，其中治疗有效量在给药过程中增加一次或两次 。