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![Method of preparing thieno[3,2-c]pyridine derivatives and intermediates used therein](/abs-image/US/2008/11/11/US07449580B2/abs.jpg.150x150.jpg)
1.发明授权Method of preparing thieno[3,2-c]pyridine derivatives and intermediates used therein 失效噻吩并[3,2-c]吡啶衍生物及其中使用的方法公开(公告)号：US07449580B2
公开(公告)日：2008-11-11
申请号：US10598790
申请日：2005-03-03
申请人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Tae Hee Ha , Kwee-Hyun Suh , Gwan Sun Lee
发明人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Tae Hee Ha , Kwee-Hyun Suh , Gwan Sun Lee
IPC分类号： C07D495/04
CPC分类号： C07D333/38 , C07D333/12 , C07D333/16 , C07D333/18 , C07D495/04
摘要： Ticlopidine and clopidogrel having high blood platelet aggregation inhibitory and anti-thrombotic activities are simply prepared by reacting a substituted thiophene derivative with a 2-chlorobenzylamine derivative.
摘要翻译： 通过使取代的噻吩衍生物与2-氯苄胺衍生物反应，简单地制备具有高血小板聚集抑制和抗血栓形成活性的噻氯匹定和氯吡格雷。
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2.发明授权Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-{(2-methyl-1H-imidazol-1-yl)methyl}-4H-carbazol-4-one 失效制备1,2,3,9-四氢-9-甲基-3 - {（2-甲基-1H-咪唑-1-基）甲基} -4H-咔唑-4-酮的方法公开(公告)号：US06388091B1
公开(公告)日：2002-05-14
申请号：US09990041
申请日：2001-11-20
申请人： Kwang-Ok Lee , Hee-Seock Kim , Young-Jin Ham , Maeng-Sup Kim , Han-Kyeng Kim , Cheol-Kyeung Kim , Kum-Sin Jung , Hoe-Chul Lee , Ki-Eun Kim , Gwan-Sun Lee
发明人： Kwang-Ok Lee , Hee-Seock Kim , Young-Jin Ham , Maeng-Sup Kim , Han-Kyeng Kim , Cheol-Kyeung Kim , Kum-Sin Jung , Hoe-Chul Lee , Ki-Eun Kim , Gwan-Sun Lee
IPC分类号： C07D23358
CPC分类号： C07D231/12 , C07D209/88 , C07D233/56 , C07D249/08 , C07D403/06
摘要： Pure -1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a pharmaceutically acceptable salt thereof is prepared in a high yield by a simple process which reacts 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one with a 2-methylimidazole derivative in an organic solvent or in a mixture of an organic solvent and water in the presence of a halosilane compound.
摘要翻译： 制备纯的-1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑-4-酮或其药学上可接受的盐 通过使1,2,3,9-四氢-9-甲基-4H-咔唑-4-酮与有机溶剂或有机溶剂和有机溶剂的混合物中的2-甲基咪唑衍生物的单一方法以高产率 水在卤代硅烷化合物存在下。
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3.发明授权Crystalline monohydrate clopidogrel naphthalenedisulfonate and process of preparation 失效结晶一水合物氯吡格雷萘二磺酸盐及其制备方法公开(公告)号：US07470707B2
公开(公告)日：2008-12-30
申请号：US10971028
申请日：2004-10-25
申请人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Bo Sung Kwon , Cheol Kyung Kim , Han Kyong Kim , Kwee-Hyun Suh , Gwan Sun Lee
发明人： Sangmin Yun , Eun Sook Kim , Hee Seock Kim , Bo Sung Kwon , Cheol Kyung Kim , Han Kyong Kim , Kwee-Hyun Suh , Gwan Sun Lee
IPC分类号： C07D495/04 , A61K31/4365
CPC分类号： C07D495/04
摘要： A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.
摘要翻译： 提供结晶氯吡格雷萘磺酸盐或其水合物，其制备方法和含有它们的药物组合物。
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