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1.发明授权Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same 有权结晶S-奥美拉唑锶水合物，其制备方法和含有它们的药物组合物公开(公告)号：US08106076B2
公开(公告)日：2012-01-31
申请号：US12425499
申请日：2009-04-17
申请人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
发明人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12
摘要： This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 本发明提供了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑水合锶，其具有高光学纯度，耐受性，溶解性和不吸湿性，其制备方法和含有该组合物的药物组合物。
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2.发明申请NOVEL CRYSTALLINE BEPOTASTINE METAL SALT HYDRATE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开新型水晶金属盐水合物，其制备方法和包含其的药物组合物公开(公告)号：US20100137367A1
公开(公告)日：2010-06-03
申请号：US12531003
申请日：2008-04-04
申请人： Tae Hee Ha , Chang Hee Park , Won Jeoung Kim , Hee Sook Oh , Seung Hwan Cho , Cheol Kyung Kim , Kwee Hyun Suh , Gwan Sun Lee
发明人： Tae Hee Ha , Chang Hee Park , Won Jeoung Kim , Hee Sook Oh , Seung Hwan Cho , Cheol Kyung Kim , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： A61K31/4545 , C07D401/12 , A61P17/00
CPC分类号： C07D401/12 , A61K9/143
摘要： The present invention discloses a non-hygroscopic crystalline bepotastine metal salt hydrate, a method for preparing same, and a pharmaceutical composition comprising same for treating or preventing a histamine-mediated disease or an allergic disease.
摘要翻译： 本发明公开了一种非吸湿结晶贝卡斯汀金属盐水合物及其制备方法，以及包含其的药物组合物，用于治疗或预防组胺介导的疾病或过敏性疾病。
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3.发明申请Crystalline S-Omeprazole Strontium Hydrate, Method For Preparing Same, And Pharmaceutical Composition Containing Same 有权结晶S-奥美拉唑锶水合物，其制备方法及含有其的药物组合物公开(公告)号：US20090258908A1
公开(公告)日：2009-10-15
申请号：US12425499
申请日：2009-04-17
申请人： Tae Hee HA , Hee Sook OH , Won Jeoung KIM , Chang Hee PARK , Eun Young KIM , Young Hoon KIM , Kwee Hyun SUH , Gwan Sun LEE
发明人： Tae Hee HA , Hee Sook OH , Won Jeoung KIM , Chang Hee PARK , Eun Young KIM , Young Hoon KIM , Kwee Hyun SUH , Gwan Sun LEE
IPC分类号： A61K31/4439 , C07D401/12 , A61P1/04
CPC分类号： C07D401/12
摘要： This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 本发明提供了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑水合锶，其具有高光学纯度，耐受性，溶解性和不吸湿性，其制备方法和含有该组合物的药物组合物。
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公开(公告)号：US20080194828A1
公开(公告)日：2008-08-14
申请号：US11996657
申请日：2006-07-11
申请人： Tae Hee Ha , Won Jeong Kim , Hee Sook Oh , Chang Hee Park , Jae Chul Lee , Han Kyong Kim , Kwee-Hyun Suh
发明人： Tae Hee Ha , Won Jeong Kim , Hee Sook Oh , Chang Hee Park , Jae Chul Lee , Han Kyong Kim , Kwee-Hyun Suh
IPC分类号： C07D401/12 , A61P1/04
CPC分类号： C07D401/12
摘要： Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(−)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(−)-binol, and removing the (S)-(−)-binol moiety from the crystallized inclusion complex.
摘要翻译： 光学纯的埃索美拉唑及其盐可以简单地通过将（S） - （ - ） - 二醇，弱碱和外消旋形式的奥美拉唑在高温下溶解在与水相容的有机溶剂和水的混合物中，冷却 混合溶液以结晶埃索美拉唑和（S） - （ - ） - 二醇的包合络合物，并从结晶的包合物中除去（S） - （ - ） - 二醇部分。
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5.发明申请CRYSTALLINE S-OMEPRAZOLE STRONTIUM HYDRATE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 有权水溶性S-奥美拉唑水合物，其制备方法和含有其的药物组合物公开(公告)号：US20110046383A1
公开(公告)日：2011-02-24
申请号：US12914032
申请日：2010-10-28
申请人： Tae Hee HA , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
发明人： Tae Hee HA , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 公开了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑锶水合物，其具有高光学纯度，耐久性，溶解性和不吸湿性，其制备方法和含有其的药物组合物。
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公开(公告)号：US07888511B2
公开(公告)日：2011-02-15
申请号：US11996657
申请日：2006-07-11
申请人： Tae Hee Ha , Won Jeong Kim , Hee Sook Oh , Chang Hee Park , Jae Chul Lee , Han Kyong Kim , Kwee-Hyun Suh
发明人： Tae Hee Ha , Won Jeong Kim , Hee Sook Oh , Chang Hee Park , Jae Chul Lee , Han Kyong Kim , Kwee-Hyun Suh
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(−)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(−)-binol, and removing the (S)-(−)-binol moiety from the crystallized inclusion complex.
摘要翻译： 光学纯的埃索美拉唑及其盐可以简单地通过将（S） - （ - ） - 二醇，弱碱和外消旋形式的奥美拉唑在高温下溶解在与水相容的有机溶剂和水的混合物中，冷却 混合溶液以结晶埃索美拉唑和（S） - （ - ） - 二醇的包合络合物，并从结晶的包合物中除去（S） - （ - ） - 二醇部分。
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7.发明授权Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same 有权结晶S-奥美拉唑锶水合物，其制备方法和含有它们的药物组合物公开(公告)号：US07576219B2
公开(公告)日：2009-08-18
申请号：US11374034
申请日：2006-03-14
申请人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
发明人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
摘要翻译： 本发明提供了一种用于预防或治疗胃酸相关疾病的结晶性S-奥美拉唑水合锶，其具有高光学纯度，耐受性，溶解性和不吸湿性，其制备方法和含有该组合物的药物组合物。
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公开(公告)号：US08513426B2
公开(公告)日：2013-08-20
申请号：US12914032
申请日：2010-10-28
申请人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
发明人： Tae Hee Ha , Hee Sook Oh , Won Jeoung Kim , Chang Hee Park , Eun Young Kim , Young Hoon Kim , Kwee Hyun Suh , Gwan Sun Lee
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
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