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    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT
    1.
    发明申请
    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 有权
    LIGNAN化合物用于抗皱治疗的用途

    公开(公告)号：US20120288579A1

    公开(公告)日：2012-11-15

    申请号：US12665206

    申请日：2009-06-20

    申请人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    发明人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    IPC分类号： A61K36/575 ,  A61K31/075 ,  A61P17/00 ,  C07D317/46 ,  C07C43/23 ,  A61K31/357 ,  C07D407/10

    CPC分类号： A61Q19/08 ,  A61K8/347 ,  A61K8/498 ,  A61K8/9789

    摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-1, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

    Use of lignan compound for anti-wrinkle treatment
    2.
    发明授权
    Use of lignan compound for anti-wrinkle treatment 有权
    使用木酚素化合物进行抗皱治疗

    公开(公告)号：US08435957B2

    公开(公告)日：2013-05-07

    申请号：US12665206

    申请日：2008-06-20

    申请人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    发明人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    IPC分类号： A61K31/70

    CPC分类号： A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

    摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。