公开(公告)号：US20140050668A1

公开(公告)日：2014-02-20

申请号：US13980751

申请日：2012-01-20

申请人： Oliver Bruns ,  Heinrich Hohenberg ,  Rudolph Reimer ,  Ulrich Tromsdorf ,  Horst Weller ,  Gerhard Adam ,  Harald Ittrich ,  Michael Kaul ,  Peter Nielsen ,  Barbara Freund ,  Alexander Bartelt ,  Jörg Heeren

发明人： Oliver Bruns ,  Heinrich Hohenberg ,  Rudolph Reimer ,  Ulrich Tromsdorf ,  Horst Weller ,  Gerhard Adam ,  Harald Ittrich ,  Michael Kaul ,  Peter Nielsen ,  Barbara Freund ,  Alexander Bartelt ,  Jörg Heeren

IPC分类号： A61K49/14

CPC分类号： A61K49/14 ,  A61K49/0004 ,  A61K49/1839

摘要： The present invention relates to the field of in vivo determination of enzyme activity. It also allows visualization of organisms, organs, tissues and cells. In particular, the present invention provides a method of in vivo visualization and a composition suitable for in vivo determination and/or visualization of enzyme activity by methods such as Magnetic Resonance Imaging, also called Magnetic Resonance Tomography (MRI or MRT), or Magnetic Particle Imaging (MPI). In particular, the activity of the enzyme lipoprotein lipase affects the signals received and allows conclusions on the lipid metabolism of an organism, an organ system, an organ, a tissue and a cell of interest, This method can be employed, e.g., for diagnosis of cardiac disorders, of tumor prognosis and of disorders of the lipid metabolism. The composition used comprises superparamagnetic iron oxide nanocrystals (SPIO) incorporated in the core of lipid micelles designated nanosomes.

摘要翻译： 本发明涉及酶活性的体内测定领域。 它还允许生物，器官，组织和细胞的可视化。 特别地，本发明提供了一种体内可视化方法和适用于体内测定和/或可视化酶活性的组合物，其通过诸如磁共振成像（Magnetic Resonance Imaging），也称为磁共振层析成像（MRI或MRT）或磁性颗粒 成像（MPI）。 特别地，酶脂蛋白脂肪酶的活性影响所接收的信号，并且允许关于生物体，器官系统，器官，组织和感兴趣的细胞的脂质代谢的结论。该方法可用于例如诊断 的心脏疾病，肿瘤预后和脂质代谢紊乱。 所使用的组合物包括掺入指定为纳米体的脂质胶束核心的超顺磁性氧化铁纳米晶体（SPIO）。