公开(公告)号：US20100184836A1

公开(公告)日：2010-07-22

申请号：US12578969

申请日：2009-10-14

Applicant: Helge ABRECHT ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Louise Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Hermann Voss

Inventor： Helge ABRECHT ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Louise Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Hermann Voss

IPC: A61K31/7088 ,  C07H21/04

CPC classification number: C07K14/005 ,  A61K2039/645 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.

Abstract translation: 本发明涉及可用于免疫原性组合物和疫苗的Gag，Pol和Nef的新型HIV多肽和多核苷酸融合体。 本发明特别涉及包含Nef或其免疫原性片段和p17 Gag和/或p24 Gag或其免疫原性片段的多肽，其中当p17和p24 Gag都存在时，存在至少一种HIV抗原或免疫原性片段 他们。 多肽还可以包含Pol或RT或其免疫原性片段。

公开(公告)号：US20070243203A1

公开(公告)日：2007-10-18

申请号：US11573128

申请日：2005-08-03

Applicant: Helge Abrecht ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Voss

Inventor： Helge Abrecht ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Voss

IPC: A61K39/395 ,  A61K38/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00

CPC classification number: C07K14/005 ,  A61K2039/645 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag; Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.

Abstract translation: 本发明涉及Gag的新型HIV多肽和多核苷酸融合物; Pol和Nef，其可用于免疫原性组合物和疫苗。 本发明特别涉及包含Nef或其免疫原性片段和p17 Gag和/或p24 Gag或其免疫原性片段的多肽，其中当p17和p24 Gag都存在时，存在至少一种HIV抗原或免疫原性片段 他们。 多肽还可以包含Pol或RT或其免疫原性片段。

公开(公告)号：US07612173B2

公开(公告)日：2009-11-03

申请号：US11573128

申请日：2005-08-03

Applicant: Helge Abrecht ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Louise Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Hermann Voss

Inventor： Helge Abrecht ,  Martine Delchambre ,  Martine Marchand ,  Nathalie Louise Mathy ,  Philippe Jean Gervais Ghislain Permanne ,  Gerald Hermann Voss

IPC: C07K14/00

CPC classification number: C07K14/005 ,  A61K2039/645 ,  C07K2319/00 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: This invention relates to novel HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.

Abstract translation: 本发明涉及可用于免疫原性组合物和疫苗的Gag，Pol和Nef的新型HIV多肽和多核苷酸融合体。 本发明特别涉及包含Nef或其免疫原性片段和p17 Gag和/或p24 Gag或其免疫原性片段的多肽，其中当p17和p24 Gag都存在时，存在至少一种HIV抗原或免疫原性片段 他们。 多肽还可以包含Pol或RT或其免疫原性片段。