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公开(公告)号：US07459587B2
公开(公告)日：2008-12-02
申请号：US12076153
申请日：2008-03-14
CPC分类号： C07C29/78 , A23L27/203 , C07B2200/07 , C07C2601/14 , C07C35/12
摘要： Crude menthol is dissolved in nitrile series solvent and then menthol is precipitated by cooling the solution to thereby obtain optically and chemically substantially pure menthol, the enantiomeric excess thereof being more than about 99% e.e. and the chemical purity being more than about 99%. Preferred examples of the nitrile series solvent include acetonitrile and propionitrile. The dissolution of crude menthol is carried out at a temperature below 42° C., which is the melting point of menthol. The cooling temperature in crystallization is preferably at a room temperature or a little lower temperature than the room temperature. After crystallization of menthol, additional purification process such as a distillation may be conducted, if necessary.
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公开(公告)号：US20080228013A1
公开(公告)日：2008-09-18
申请号：US12076153
申请日：2008-03-14
IPC分类号： C07C37/68
CPC分类号： C07C29/78 , A23L27/203 , C07B2200/07 , C07C2601/14 , C07C35/12
摘要： Crude menthol is dissolved in nitrile series solvent and then menthol is precipitated by cooling the solution to thereby obtain optically and chemically substantially pure menthol, the enantiomeric excess thereof being more than about 99% e.e. and the chemical purity being more than about 99%. Preferred examples of the nitrile series solvent include acetonitrile and propionitrile. The dissolution of crude menthol is carried out at a temperature below 42° C., which is the melting point of menthol. The cooling temperature in crystallization is preferably at a room temperature or a little lower temperature than the room temperature. After crystallization of menthol, additional purification process such as a distillation may be conducted, if necessary.
摘要翻译： 将粗薄荷醇溶解在腈系溶剂中，然后通过冷却溶液沉淀薄荷醇，从而获得光学和化学上基本上纯的薄荷醇，其对映异构体超过约99％e.e。 化学纯度大于约99％。 腈系溶剂的优选实例包括乙腈和丙腈。 粗薄荷醇的溶解在低于42℃的温度下进行，这是薄荷醇的熔点。 结晶中的冷却温度优选为室温或稍低于室温的温度。 在薄荷醇结晶后，如果需要，可以进行另外的纯化方法如蒸馏。
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