公开(公告)号：US06306853B1

公开(公告)日：2001-10-23

申请号：US09622086

申请日：2000-08-10

申请人： Shigeyuki Tasaka ,  Akira Kiue ,  Hiromasa Omori ,  Hirokazu Tanabe ,  Noriaki Gomi

发明人： Shigeyuki Tasaka ,  Akira Kiue ,  Hiromasa Omori ,  Hirokazu Tanabe ,  Noriaki Gomi

IPC分类号： C07D4012

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04

摘要： A 1,4-dihydropyridine derivative having the formula (I): wherein, R1 represents a substituted or unsubstituted phenyl or pyridyl group, R2 represents a C1 to C5 lower alkyl group, R3 represents a substituted or unsubstituted C1 to C8 alkyl, alkenyl, alkynyl or substituted or unsubstituted C3 to C7 cycloalkyl or cycloalkenyl group, R4 represents —A—R5, wherein A represents a C3 to C5 alkynylene group having one triple bond, and R5 represents a substituted or unsubstituted pyridyl, quinolyl, isoquinolyl or pyrimidyl group and a drug for overcoming resistance to an anti-cancer drug or a drug increasing the effect of an anti-cancer drug containing as an effective ingredient the derivative or its pharmacologically acceptable salt or hydrate.

摘要翻译： 具有式（I）的1,4-二氢吡啶衍生物：其中，R1表示取代或未取代的苯基或吡啶基，R2表示C1至C5低级烷基，R3表示取代或未取代的C1至C8烷基，烯基， 炔基或取代或未取代的C3至C7环烷基或环烯基，R4表示-A-R5，其中A表示具有一个三键的C3至C5亚炔基，R5表示取代或未取代的吡啶基，喹啉基，异喹啉基或嘧啶基， 用于克服抗癌药物或药物的药物，其增加了含有作为有效成分的衍生物或其药理学上可接受的盐或水合物的抗癌药物的作用。