公开(公告)号：US07375085B1

公开(公告)日：2008-05-20

申请号：US09926391

申请日：2000-04-25

申请人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

发明人： Eiji Shiojiri ,  Yoshinobu Takino ,  Hiromi Chujou ,  Kazutami Sakamoto ,  Chiori Ijichi ,  Yuzuru Eto ,  Keiji Iwasaki

IPC分类号： C07K5/08 ,  A61K38/00

CPC分类号： C07K5/0812 ,  A61K38/00

摘要： In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.

摘要翻译： 在本说明书中公开了一种黑素细胞刺激激素抑制组合物，其包含作为活性成分的具有某个萘基的二肽或三肽衍生物或其盐，或具有50％抑制性的黑素细胞刺激激素抑制化合物 cAMP产生浓度（IC 50）为100nM以下，该组合物可以防止色素沉积，或者可以防止，改善或恢复免疫异常或免疫缺陷，或通过食欲控制来调节体重，并且还可以用作化妆品或外用制剂 并且另外可以容易地制造，并且在保存期间的稳定性优异。