公开(公告)号：US06470592B2

公开(公告)日：2002-10-29

申请号：US09797834

申请日：2001-03-05

申请人： Hiromiti Akimoto ,  Ryouji Sunama

发明人： Hiromiti Akimoto ,  Ryouji Sunama

IPC分类号： F26B506

CPC分类号： F26B5/06 ,  F26B5/065

摘要： A process is provided for freeze-drying medicaments and foodstuffs comprising dissolving the foodstuffs or medicaments in a solvent, introducing the solution formed into a shell comprising a desiccating chamber of a shell-tube freeze-drying device to cause the solution to freeze in a tubular layer, and crushing and comminuting the freeze-dried liquid with a comminuting device to obtain a powder product.

摘要翻译： 提供了一种冷冻干燥药物和食品的方法，包括将食品或药物溶解在溶剂中，将形成的溶液引入包含壳管式冷冻干燥装置的干燥室的壳体中，使溶液冷冻成管状 层压，并用粉碎装置粉碎和粉碎冷冻干燥液体，得到粉末产品。

公开(公告)号：US06464385B2

公开(公告)日：2002-10-15

申请号：US09811571

申请日：2001-03-20

申请人： Hiromiti Akimoto ,  Ryouji Sunama

发明人： Hiromiti Akimoto ,  Ryouji Sunama

IPC分类号： B01F1306

CPC分类号： B01F13/065 ,  B01F1/00 ,  B01F3/1271 ,  B01F5/10 ,  B01F2003/125

摘要： A material blending tank 1 is formed in a pressure-resistant, and tightly closable vessel, in its inner cavity, into which predetermined quantities of starting materials are charged, followed by hermetically sealing the tank; a material adjusting tank 2 is formed in a large size, into which a predetermined quantity of solvent is filled so as to be able to pump out from its bottom part by means of a pump P; the pump P functioning to pressure-feeding the solvent pumped out of the material adjusting tank 2 into the inner cavity of the material blending tank 1 through its bottom side. In the course of the pressure-feeding of the solvent, when the air within the material blending tank 1 is compressed to a high pressure level, the operation of the pump P is stopped and the solvent which has been pressure-fed into the material blending tank 1 is subjected to reverse flow through the inner cavity of the pump P into the material adjusting tank 2 by the pressure of the air compressed in the material blending tank 1. Subsequently, the process steps of: the pressure-feeding of the solvent into the material blending tank 1 due to re-starting of the pump P; and the reverse flow of the solvent into the material adjusting tank 2 due to stoppage of the pump P are repeated for a plurality of number of times to dissolve the starting materials into the solvent, thereby making it into slurry.

摘要翻译： 材料混合罐1在其内腔中的耐压且可紧密封闭的容器中形成，其中装入预定量的起始材料，然后气密地密封罐; 以大尺寸形成材料调节罐2，其中填充有预定量的溶剂，以便能够通过泵P从其底部泵出; 泵P用于将从材料调节罐2泵出的溶剂从其底侧压入到混合料斗1的内腔中。 在溶剂的加压过程中，当将混合料箱1内的空气压缩至高压时，停止泵P的运转，并将已加压进料的溶剂混入 罐1经由泵浦P的内腔经过在料料1中压缩的空气的压力而反向流入材料调节罐2.随后，将溶剂压入 由于泵P的重新启动，材料混合槽1; 并且由于泵P的停止而使溶剂向材料调节槽2的反向流动重复多次以将原料溶解到溶剂中，从而使其成为浆料。