公开(公告)号：US06623740B1

公开(公告)日：2003-09-23

申请号：US09114002

申请日：1998-07-10

申请人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

发明人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

IPC分类号： A61K3800

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  Y10S514/885

摘要： Human melanoma cells bear antigens that are recognized by autologous CD8+ cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically.

摘要翻译： 人黑素瘤细胞承载由自体CD8 +细胞毒性T淋巴细胞识别的抗原。 本发明涉及通过HLA分子接收MZ2-E抗原的特定肽类似物。 本文公开了经修饰以抵抗肽酶降解的肿瘤抗原MZ2-E的肽类似物，并且其结合HLA分子以形成其特异性溶细胞T细胞的识别导致复合物裂解的复合物。 肽类似物/ HLA复合物的溶细胞T细胞的鉴定可用于诊断或治疗。