公开(公告)号：US08257743B2

公开(公告)日：2012-09-04

申请号：US12443004

申请日：2007-06-29

申请人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

发明人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

IPC分类号： A61K9/14 ,  A61K33/24

CPC分类号： C08J3/12 ,  A61K9/5153 ,  A61K9/5192 ,  C08J2329/04

摘要： Disclosed herein are multifunctional nanoparticles, comprising: polymer nanoparticles formed by loading a drug into a polymer; a gold thin film deposited on a portion of the surface of the polymer nanoparticles; and an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered, the antibody being conjugated to the gold thin film. Also disclosed is a method for preparing multifunctional nanoparticles, the method comprising the steps of: loading a drug into a polymer to prepare polymer nanoparticles; depositing a portion of the surface of the polymer nanoparticles with a gold thin film; conjugating to the gold thin film an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered; and separating from the resulting nanoparticles those in which a portion of the surface of the polymer nanoparticles is deposited with the gold thin film and conjugated with the antibody. Furthermore, disclosed are a composition containing the multifunctional nanoparticles and a method for diagnosing and treating disease using the composition.

摘要翻译： 本文公开了多功能纳米颗粒，其包括：通过将药物加载到聚合物中形成的聚合物纳米颗粒; 沉积在聚合物纳米颗粒表面的一部分上的金薄膜; 以及针对在药物要被递送的细胞的表面上表达的物质的抗体，所述抗体与金薄膜缀合。 还公开了一种制备多功能纳米颗粒的方法，所述方法包括以下步骤：将药物装载到聚合物中以制备聚合物纳米颗粒; 用金薄膜沉积聚合物纳米颗粒表面的一部分; 与金薄膜缀合对在药物将要递送的细胞表面上表达的物质的抗体; 并从所得到的纳米颗粒中分离，其中聚合物纳米颗粒的一部分表面用金薄膜沉积并与抗体缀合。 此外，公开了含有多功能纳米颗粒的组合物和使用该组合物诊断和治疗疾病的方法。

公开(公告)号：US20100028453A1

公开(公告)日：2010-02-04

申请号：US12443004

申请日：2007-06-29

申请人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

发明人： Kyung Hwa Yoo ,  Jeon Soo Shin ,  Seungjoo Haam ,  Hui Yul Park ,  Jaemoon Yang

IPC分类号： A61K9/16 ,  A61K39/395

CPC分类号： C08J3/12 ,  A61K9/5153 ,  A61K9/5192 ,  C08J2329/04

摘要： Disclosed herein are multifunctional nanoparticles, comprising: polymer nanoparticles formed by loading a drug into a polymer; a gold thin film deposited on a portion of the surface of the polymer nanoparticles; and an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered, the antibody being conjugated to the gold thin film. Also disclosed is a method for preparing multifunctional nanoparticles, the method comprising the steps of: loading a drug into a polymer to prepare polymer nanoparticles; depositing a portion of the surface of the polymer nanoparticles with a gold thin film; conjugating to the gold thin film an antibody to a substance expressed on the surface of a cell to which the drug is to be delivered; and separating from the resulting nanoparticles those in which a portion of the surface of the polymer nanoparticles is deposited with the gold thin film and conjugated with the antibody. Furthermore, disclosed are a composition containing the multifunctional nanoparticles and a method for diagnosing and treating disease using the composition.

摘要翻译： 本文公开了多功能纳米颗粒，其包括：通过将药物加载到聚合物中形成的聚合物纳米颗粒; 沉积在聚合物纳米颗粒表面的一部分上的金薄膜; 以及针对在药物要被递送的细胞的表面上表达的物质的抗体，所述抗体与金薄膜缀合。 还公开了一种制备多功能纳米颗粒的方法，所述方法包括以下步骤：将药物装载到聚合物中以制备聚合物纳米颗粒; 用金薄膜沉积聚合物纳米颗粒表面的一部分; 与金薄膜缀合对在药物将要递送的细胞表面上表达的物质的抗体; 并从所得到的纳米颗粒中分离，其中聚合物纳米颗粒的一部分表面用金薄膜沉积并与抗体缀合。 此外，公开了含有多功能纳米颗粒的组合物和使用该组合物诊断和治疗疾病的方法。