公开(公告)号：US20060148706A1

公开(公告)日：2006-07-06

申请号：US11361560

申请日：2006-02-24

Applicant: Hua-Lin Wu ,  Guey-Yueh Shi ,  Chuan-Chi Chiang ,  Hui-Pin Su

Inventor： Hua-Lin Wu ,  Guey-Yueh Shi ,  Chuan-Chi Chiang ,  Hui-Pin Su

IPC: A61K38/18

CPC classification number: A61K48/00 ,  A61K38/366

Abstract: The invention relates to a method for treatment of wound healing, comprising administering to a patient in need of such treatment with an effective amount of a polypeptide comprising amino acid sequence or a conservative variant thereof having EGF-like domain of thrombomodulin. The invention also relates to a composition for the use of accelerating wound healing, comprising a polypeptide comprising amino acid sequence or a conservative variant thereof having EGF-like domain of thrombomodulin.

Abstract translation: 本发明涉及一种治疗伤口愈合的方法，其包括向需要这种治疗的患者施用有效量的包含氨基酸序列的多肽或其具有血栓调节蛋白EGF样结构域的保守变体。 本发明还涉及用于加速伤口愈合的组合物，其包含含有氨基酸序列的多肽或其具有血栓调节蛋白的EGF样结构域的保守变体。

公开(公告)号：US20070203164A1

公开(公告)日：2007-08-30

申请号：US11361589

申请日：2006-02-24

Applicant: Chuan-Chi Chiang ,  Hui-Pin Su ,  Hua-Lin Wu ,  Guey-Yueh Shi

Inventor： Chuan-Chi Chiang ,  Hui-Pin Su ,  Hua-Lin Wu ,  Guey-Yueh Shi

IPC: A61K31/485

CPC classification number: A61K31/485 ,  Y10S514/859

Abstract: The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compound of dextromethorphan or naloxone or a pharmaceutically acceptable salt or an analog thereof. The compound is applied to skin or mucosal surface of the patient. The invention also relates to a method of treating inflammation caused by suppressing secretion of TNF-α, IL-6, or MCP-1 from macrophage comprising administering a patient in need of such treatment a therapeutically effective amount of NADPH oxidase inhibitor.

Abstract translation: 本发明涉及一种提供杀菌剂或抑菌剂的方法，特别是用于治疗由细菌感染引起的疾病。 该方法包括给予需要这种治疗的患者治疗有效量的右美沙芬或纳洛酮或其药学上可接受的盐或类似物的化合物。 该化合物应用于患者的皮肤或粘膜表面。 本发明还涉及一种治疗由巨噬细胞抑制TNF-α，IL-6或MCP-1分泌引起的炎症的方法，包括给予需要这种治疗的患者治疗有效量的NADPH氧化酶抑制剂。