公开(公告)号：US08299125B2

公开(公告)日：2012-10-30

申请号：US12743101

申请日：2008-11-05

申请人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

发明人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

IPC分类号： C07C309/27 ,  A61K31/216 ,  A61K31/192

CPC分类号： C07J63/00 ,  C07J63/008

摘要： The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.

摘要翻译： 本发明公开了具有由式（I）表示的抗肿瘤活性的水溶性三硝基苯酚化合物，其中取代基R 1〜R 4和M如说明书中所定义。 本发明还公开了使用醌甲基化三萜化合物作为原料制备式（I）化合物的方法。 本发明公开的水溶性三萜烯化合物可以制成各种剂型，包括注射剂，片剂，胶囊剂，颗粒剂和搽剂，特别适用于注射。

公开(公告)号：US20100267983A1

公开(公告)日：2010-10-21

申请号：US12743101

申请日：2008-11-05

申请人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

发明人： Jiafeng Zeng ,  Junfang Pan ,  Baoying Li ,  Qin Zhu ,  Tong Fang ,  Huiyan Ni

IPC分类号： C07C309/60 ,  C07C69/753

CPC分类号： C07J63/00 ,  C07J63/008

摘要： The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.

摘要翻译： 本发明公开了具有由式（I）表示的抗肿瘤活性的水溶性三硝基苯酚化合物，其中取代基R 1〜R 4和M如说明书中所定义。 本发明还公开了使用醌甲基化三萜化合物作为原料制备式（I）化合物的方法。 本发明公开的水溶性三萜烯化合物可以制成各种剂型，包括注射剂，片剂，胶囊剂，颗粒剂和搽剂，特别适用于注射。