公开(公告)号：US08758769B2

公开(公告)日：2014-06-24

申请号：US12083195

申请日：2007-08-28

申请人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

发明人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

IPC分类号： A61K36/02 ,  A61K8/97

CPC分类号： A61K8/975 ,  A61K38/011 ,  Y10S435/814 ,  Y10S514/893

摘要： Disclosed is a composition for preventing and treating acetaminophen induced liver injury including the protein extracted from Porphyra yezoensis. The protein(s), separated and purified from hot water extracts of Porphyra yezoensis, having the molecular weight of 14 kDa measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis, has an excellent effect for inhibiting the oxidative injury of liver tissue and cell apoptosis of liver cells induced by acetaminophen.

摘要翻译： 公开了一种用于预防和治疗对乙酰氨基酚诱发的肝损伤的组合物，包括从紫菜属中提取的蛋白质。 通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳测定的具有14kDa分子量的紫菜紫菜热水提取物中分离纯化的蛋白质对抑制肝组织氧化损伤和肝细胞凋亡具有极好的作用 对乙酰氨基酚诱导的细胞。

公开(公告)号：US20100152422A1

公开(公告)日：2010-06-17

申请号：US12083195

申请日：2007-08-28

申请人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

发明人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

IPC分类号： C07K14/415

CPC分类号： A61K8/975 ,  A61K38/011 ,  Y10S435/814 ,  Y10S514/893

摘要： The present invention relates to a composition for preventing and treating acetaminophen induced liver injury comprising the protein extracts from porphyra yezoensis. The protein separated and purified from hot water extracts of porphyra yezoensis and having the molecular weight of 14 kDa measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis manner has an excellent effect for inhibiting the oxidative injury of the liver tissue and the cell apoptosis of the liver cell induced by acetaminophen.

摘要翻译： 本发明涉及一种用于预防和治疗对乙酰氨基酚诱发的肝损伤的组合物，其包含来自紫花苜蓿的蛋白质提取物。 通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳方法测定的分离纯度为十五烷基硫酸钠的分子量为14kDa的紫花苜蓿热水提取物，对抑制肝组织氧化损伤和肝细胞凋亡具有极好的疗效 由对乙酰氨基酚诱导。