公开(公告)号：US20080200536A1

公开(公告)日：2008-08-21

申请号：US12063090

申请日：2006-06-26

Applicant: Joo Myung Moon ,  Hyun-Ah Lee

Inventor： Joo Myung Moon ,  Hyun-Ah Lee

IPC: A61K31/365

CPC classification number: A61K9/2095 ,  A61K9/143 ,  A61K9/145

Abstract: Disclosed herein are a pharmaceutical formulation with high stability and dissolution, and a method for preparing the pharmaceutical formulation. The pharmaceutical formulation comprises a pharmacologically active substance, a solvent, a solubilizer, a surfactant, an antioxidant, and an adsorbent. According to the pharmaceutical formulation and the method, the pharmacologically active substance is mixed with the solvent, the solubilizer agent and the surfactant for improving the solubility of the pharmacologically active substance to obtain an amorphous liquid or semi-solid state, the antioxidant is melted together with the mixture to solve poor chemical stability of the pharmacologically active substance in an amorphous or liquid state, and the adsorbent is strongly adsorbed to the molten mixture so as to be transformed into a powder form so that the resulting molecules are reconstituted into very tiny crystal forms within the adsorbent to ensure chemical stability.

Abstract translation: 本文公开了具有高稳定性和溶解性的药物制剂，以及制备药物制剂的方法。 药物制剂包含药理活性物质，溶剂，增溶剂，表面活性剂，抗氧化剂和吸附剂。 根据药物制剂和方法，将药理活性物质与溶剂，增溶剂和表面活性剂混合以提高药理活性物质的溶解度，得到无定形液体或半固体状态，抗氧化剂熔融在一起 该混合物解决药物活性物质在无定形或液体状态下的差的化学稳定性，并且吸附剂被强烈地吸附到熔融混合物中，以便转化为粉末形式，使得所得分子重构成非常微小的晶体 在吸附剂内形成，以确保化学稳定性。

公开(公告)号：US20210198011A1

公开(公告)日：2021-07-01

申请号：US16066062

申请日：2016-12-21

Applicant: Een Suk PARK ,  Hyun Seo LEE ,  Hyun Jung LEE ,  Hyun Ah LEE

Inventor： Een Suk PARK ,  Hyun Seo LEE ,  Hyun Jung LEE ,  Hyun Ah LEE

IPC: B65D33/10 ,  B65D88/22

Abstract: Disclosed is a bulk bag having self-standing loops. The bulk bag is configured with a bag-shaped body having a reversed “U”-shaped loop protruding upwardly from an outside thereof and configured to flexibly stand upright by itself from a folded position upon unstacking of bodies, wherein the loop is coupled to the body at a position spaced downwardly apart from a top edge of the body by a predetermined distance, the loop having an air tube having a predetermined length and coupled to an outside of the loop. The loop is configured with a semicircular arc-shaped hook portion and “I”-shaped supporting portions respectively extending from opposite ends of the hook portion, and the air tube is coupled with the hook portion and an at least one supporting portion and is heat-treated and flexibly bent at a portion corresponding to a boundary point between the hook portion and the supporting portion.