公开(公告)号：US06416991B1

公开(公告)日：2002-07-09

申请号：US09595514

申请日：2000-06-14

申请人： Stephen C. Phillips ,  Jerry Lanfear ,  Lindsay Fawcett ,  Olga Bandman ,  Ian Harrow

发明人： Stephen C. Phillips ,  Jerry Lanfear ,  Lindsay Fawcett ,  Olga Bandman ,  Ian Harrow

IPC分类号： C12N916

CPC分类号： C12Y301/04017 ,  A61K38/00 ,  C12N9/16

摘要： The invention provides human cyclic nucleotide phosphodiesterases (HSPDE10A) and polynucleotides which identify and encode HSPDE10A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists and methods for diagnosing or treating disorders associated with expression of HSPDE10A.

摘要翻译： 本发明提供了人类环核苷酸磷酸二酯酶（HSPDE10A）和识别和编码HSPDE10A的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂以及用于诊断或治疗与HSPDE10A表达相关的疾病的方法。

公开(公告)号：US20060121550A1

公开(公告)日：2006-06-08

申请号：US10137498

申请日：2002-04-29

申请人： Martyn Burslem ,  Ian Harrow ,  Jeremy Lanfear ,  Stephen Phillips ,  Christopher Wayman

发明人： Martyn Burslem ,  Ian Harrow ,  Jeremy Lanfear ,  Stephen Phillips ,  Christopher Wayman

IPC分类号： C12Q1/42 ,  A61K31/519

CPC分类号： A61K31/519 ,  C12Q1/42

摘要： The invention provides genetically modified non-human mammals and genetically modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A. The invention also provides agents and methods relating to the effect of PDE11A modulation (i.e. PDE11A inhibition or stimulation) on ex vivo spermatozoa capacitation and PDE11A stimulation on in vivo spermatozoa capacitation. The invention also relates to the effect of PDE11A modulation on male pro-fertility and female sexual dysfunction (FSD), specifically female sexual arousal disorder (FSAD), female orgasmic disorder (FOD), hypoactive sexual desire disorder (HSDD) or sexual pain disorders.

摘要翻译： 本发明提供了遗传修饰的非人哺乳动物和含有功能性破坏的PDE11A基因的遗传修饰的动物细胞。 本发明还提供筛选调节PDE11A以调节精子发生的药剂的方法，治疗哺乳动物以调节精子发生的方法，以及在表达PDE11A的细胞中调节cAMP和cGMP信号转导的方法。 本发明还提供了与PDE11A调节（即PDE11A抑制或刺激）对离体精子获能和PDE11A刺激对体内精子获能的影响有关的药剂和方法。 本发明还涉及PDE11A调节对男性生殖能力和女性性功能障碍（FSD），特别是女性性唤起障碍（FSAD），女性高潮症（FOD），低反应性欲欲障碍（HSDD）或性疼痛障碍 。