公开(公告)号：US20080237538A1

公开(公告)日：2008-10-02

申请号：US10590167

申请日：2005-02-14

申请人： Ian V.J. Archer ,  Noel A. Hamill

发明人： Ian V.J. Archer ,  Noel A. Hamill

IPC分类号： C01B21/092 ,  C09K3/00

CPC分类号： C01B21/0926

摘要： There is provided a process for preparing a lithium amide composition in which in a first step lithium metal is brought into contact with ammonia to form lithium bronze and in a second step the lithium bronze is reacted with a 1,3-diene or an arylolefin, such as butadiene, isoprene, piperylene, dimethylbutadiene, hexadiene, styrene, methyl styrene, divinylbenzene, naphthalene or anthracene, in the presence of a solvent wherein the temperature is maintained at or below the boiling point of ammonia. Examples of solvents include pentane, cyclopentane, hexane, heptane, octane, cyclohexane, toluene, xylene, cumene, ethyl benzene, tetraline, diethyl ether, tetrahydrofuran (THF), 2-methyl-THF, tetrahydropyran, diisopropyl ether, dibutyl ether, dioxan, methyl-tert-butyl ether or glycol ether. Lithium amide compositions obtainable by said process show improved activity, particularly in reactions involving enolate formation.

摘要翻译： 提供了一种制备氨基锂组合物的方法，其中在第一步中，使锂金属与氨接触形成青铜，第二步是将青铜与1,3-二烯烃或芳烃烯烃反应， 例如丁二烯，异戊二烯，戊间二烯，二甲基丁二烯，己二烯，苯乙烯，甲基苯乙烯，二乙烯基苯，萘或蒽在溶剂存在下，其中温度保持在氨或沸点以下。 溶剂的实例包括戊烷，环戊烷，己烷，庚烷，辛烷，环己烷，甲苯，二甲苯，枯烯，乙苯，四氢化萘，乙醚，四氢呋喃（THF），2-甲基THF，四氢吡喃，二异丙基醚，二丁醚，二恶烷 ，甲基叔丁基醚或二醇醚。 通过所述方法可获得的酰胺组合物显示改善的活性，特别是在涉及烯醇化物形成的反应中。