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1.发明申请METHODS AND COMPOSITIONS TO DETECT THE LEVEL OF LYSOSOMAL EXOCYTOSIS ACTIVITY AND METHODS OF USE 有权检测LYSOSOMAL EXOCYTOSIS活动水平的方法和组合及使用方法公开(公告)号：US20140377245A9
公开(公告)日：2014-12-25
申请号：US14239728
申请日：2012-08-28
CPC分类号： C12Q1/34 , A61K38/47 , A61K38/48 , A61K38/4813 , C12Y302/01018 , G01N33/573 , G01N33/57484 , G01N33/57496 , G01N2333/924 , G01N2800/2821 , G01N2800/56 , G06F19/00 , G06F19/34
摘要： Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile. As such, the level of lysosomal exocytosis activity and/or lysosomal sialidase activity is predictive of a diagnosis and/or prognosis of cancer, chemotherapy resistance or dementia associated with Alzheimer's disease.
摘要翻译： 提供了各种病理状态的预后，诊断和治疗方法，包括与阿尔茨海默氏病有关的癌症，耐化学药物和痴呆症。 本文提供的方法基于以下发现：具有高水平唾液酸化的各种蛋白质在本文中显示为与疾病状态相关，例如与阿尔茨海默氏病相关的癌症，化疗耐药性和痴呆。 这样的方法提供了包含一个或多个代表溶酶体胞吐作用活性的值的溶酶体胞吐活性谱。 这里也提供了低溶酶体唾液酸酶活性与各种病理状态相关的发现。 因此，所述方法还提供溶酶体唾液酸酶活性谱，其包含一个或多个表示溶酶体唾液酸酶活性的值。 溶酶体唾液酸酶活性谱是溶酶体胞吐活性谱的一个实例。 因此，溶酶体胞吐作用和/或溶酶体唾液酸酶活性的水平预示着与阿尔茨海默氏病相关的癌症，耐化学药物或痴呆症的诊断和/或预后。
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2.发明申请公开(公告)号：US20140193392A1
公开(公告)日：2014-07-10
申请号：US14239728
申请日：2012-08-28
CPC分类号： C12Q1/34 , A61K38/47 , A61K38/48 , A61K38/4813 , C12Y302/01018 , G01N33/573 , G01N33/57484 , G01N33/57496 , G01N2333/924 , G01N2800/2821 , G01N2800/56 , G06F19/00 , G06F19/34
摘要： Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile. As such, the level of lysosomal exocytosis activity and/or lysosomal sialidase activity is predictive of a diagnosis and/or prognosis of cancer, chemotherapy resistance or dementia associated with Alzheimer's disease.
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3.发明授权Methods of treating alzheimer's disease by administration of protective protein/cathepsin A 有权通过给予保护性蛋白/组织蛋白酶治疗阿尔茨海默病的方法A公开(公告)号：US09399791B2
公开(公告)日：2016-07-26
申请号：US14239728
申请日：2012-08-28
申请人： Ida Annunziata , Alessandra D'Azzo
发明人： Ida Annunziata , Alessandra D'Azzo
IPC分类号： A61K38/47 , C12Q1/34 , G01N33/574 , A61K38/48 , G06F19/00
CPC分类号： C12Q1/34 , A61K38/47 , A61K38/48 , A61K38/4813 , C12Y302/01018 , G01N33/573 , G01N33/57484 , G01N33/57496 , G01N2333/924 , G01N2800/2821 , G01N2800/56 , G06F19/00 , G06F19/34
摘要： Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile. As such, the level of lysosomal exocytosis activity and/or lysosomal sialidase activity is predictive of a diagnosis and/or prognosis of cancer, chemotherapy resistance or dementia associated with Alzheimer's disease.
摘要翻译： 提供了各种病理状态的预后，诊断和治疗方法，包括与阿尔茨海默氏病有关的癌症，耐化学药物和痴呆症。 本文提供的方法基于以下发现：具有高水平唾液酸化的各种蛋白质在本文中显示为与疾病状态相关，例如与阿尔茨海默氏病相关的癌症，化疗耐药性和痴呆。 这样的方法提供了包含一个或多个代表溶酶体胞吐作用活性的值的溶酶体胞吐活性谱。 这里也提供了低溶酶体唾液酸酶活性与各种病理状态相关的发现。 因此，所述方法还提供溶酶体唾液酸酶活性谱，其包含一个或多个表示溶酶体唾液酸酶活性的值。 溶酶体唾液酸酶活性谱是溶酶体胞吐活性谱的一个实例。 因此，溶酶体胞吐作用和/或溶酶体唾液酸酶活性的水平预示着与阿尔茨海默氏病相关的癌症，耐化学药物或痴呆症的诊断和/或预后。
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