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1.发明申请CLONING AND RECOMBINANT PRODUCTIONS OF VESPULA VENOM PROTEASE AND METHODS OF USE THEREOF 有权VESPULA VENOM PROTEASE的克隆和重组生产及其使用方法公开(公告)号：US20120009187A1
公开(公告)日：2012-01-12
申请号：US13254644
申请日：2010-03-03
申请人： Henning Seismann , Ingke Braren , Thomas Grunwald
发明人： Henning Seismann , Ingke Braren , Thomas Grunwald
IPC分类号： A61K39/395 , A61K38/48 , G01N33/573 , C12N9/96 , C12N9/50 , C07H21/04 , A61P37/08 , C12N1/21 , C12N1/19 , C40B30/04 , A61K31/7088 , A61K38/54 , C12N5/10
CPC分类号： A61K39/35 , C12N9/6418
摘要： The invention relates to nucleic acids encoding a novel Vespula venom protease or fragments thereof, in particular the protease Ves v 4, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to the expression of such nucleic acids to produce a recombinant Vespula venom protease, or recombinant fragments thereof, or synthetic peptides thereof. Such a protease or fragments thereof or synthetic peptides thereof are useful for diagnosis of insect venom allergy and for therapeutic treatment of insect venom allergy.
摘要翻译： 本发明涉及编码新型蛇毒毒蛋白酶或其片段的核酸，特别是蛋白酶Ves v4，包含该核酸的重组载体和含有重组载体的宿主细胞。 本发明进一步涉及这种核酸的表达以产生重组Vespula毒液蛋白酶或其重组片段或其合成肽。 这种蛋白酶或其片段或其合成肽可用于昆虫毒液过敏的诊断和昆虫毒液过敏的治疗处理。
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2.发明授权Chimera of human IgE receptor α-chain and avian constant immuno-globulin domains for the determination of serum IgE 有权人类IgE受体α链和鸟类恒定免疫球蛋白结构域的嵌合体，用于测定血清IgE公开(公告)号：US07897153B1
公开(公告)日：2011-03-01
申请号：US11581874
申请日：2006-10-17
IPC分类号： A61K39/00
CPC分类号： C07K16/4291 , C07K14/70535 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2319/30 , G01N33/6854
摘要： The instant application inter alia relates to chimeric fusion constructs comprising the extracellular portion of human FcεRIα and at least one avian constant immunoglobulin domain and the use thereof for in vitro diagnostic purposes.
摘要翻译： 本申请尤其涉及包含人FcγRIα的细胞外部分和至少一种禽类恒定免疫球蛋白结构域的嵌合融合构建体及其用于体外诊断目的的用途。
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3.发明授权Cloning and recombinant productions of Vespula venom protease and methods of use thereof 有权Vespula毒液蛋白酶的克隆和重组产物及其使用方法公开(公告)号：US08802836B2
公开(公告)日：2014-08-12
申请号：US13254644
申请日：2010-03-03
申请人： Henning Seismann , Ingke Braren , Thomas Grunwald
发明人： Henning Seismann , Ingke Braren , Thomas Grunwald
CPC分类号： A61K39/35 , C12N9/6418
摘要： The invention relates to nucleic acids encoding a novel Vespula venom protease or fragments thereof, in particular the protease Ves v 4, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to the expression of such nucleic acids to produce a recombinant Vespula venom protease, or recombinant fragments thereof, or synthetic peptides thereof. Such a protease or fragments thereof or synthetic peptides thereof are useful for diagnosis of insect venom allergy and for therapeutic treatment of insect venom allergy.
摘要翻译： 本发明涉及编码新型蛇毒毒蛋白酶或其片段的核酸，特别是蛋白酶Ves v4，包含该核酸的重组载体和含有重组载体的宿主细胞。 本发明进一步涉及这种核酸的表达以产生重组Vespula毒液蛋白酶或其重组片段或其合成肽。 这种蛋白酶或其片段或其合成肽可用于昆虫毒液过敏的诊断和昆虫毒液过敏的治疗处理。
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