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公开(公告)号：US09693785B2
公开(公告)日：2017-07-04
申请号：US14321925
申请日：2014-07-02
Applicant: Inova Health System
Inventor： Mark Theiss , Jihui Li
CPC classification number: A61B17/175 , A61B17/1746 , A61B2017/568 , A61F2/30942 , A61F2/4609 , A61F2002/4687
Abstract: A device for use in total hip arthroplasty surgery including a first guide member having a substantially semi-circular ring having a top surface and a bottom surface, a plurality of first guide legs protruding vertically downward from the lower surface of the semi-circular ring, the first guide legs including a contact area disposed on the open end of the first guide leg; a plurality of holes disposed on the ring, a plurality of protrusions extending vertically upward from a top surface of the ring. The device also includes a second guide member having an arc having an arc of curvature substantially similar to the semi-circular ring, the arc having a top surface and bottom surface, first and second horizontal brackets connecting ends of the arc and being connected thereto at a termination point, a plurality of second guide legs protruding vertically from either the lower surface of the arc, first or second horizontal brackets; and means for connecting the second guide member to the first guide member. The device also includes third and fourth guide members.
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公开(公告)号：US20170011168A1
公开(公告)日：2017-01-12
申请号：US15249409
申请日：2016-08-27
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications. Provided herein is a method of using an ancestral-specific reference genome in genome sequencing.
Abstract translation: 祖先对基因组内每个核苷酸位置发现的主要和次要等位基因具有显着影响。 由于遗传机制，祖先特异性信息包含在基因组内，在祖先的成员中是保守的。 因此，特定祖先的个体更有可能与同一祖先的其他成员共享基因组中的等位基因。 功能上，一组个体内的所有位置上的等位基因的组合将该组定义为具有共同的祖先。 此外，所有位置的等位基因之间的差异的聚集将一个祖先与另一个祖先区分开。 祖先之间的基因组相似性和差异提供了生成对每个祖先特异的参考基因组的机制。 可以使用对祖先特异性的参考基因组来提高全基因组测序，基于DNA的诊断和治疗标记发现的准确性，以及各种真实的基于DNA的应用。 本文提供了在基因组测序中使用祖先特异性参考基因组的方法。
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3.发明申请公开(公告)号：US20150012001A1
公开(公告)日：2015-01-08
申请号：US14321925
申请日：2014-07-02
Applicant: Inova Health System
Inventor： Mark Theiss , Jihui LI
CPC classification number: A61B17/175 , A61B17/1746 , A61B2017/568 , A61F2/30942 , A61F2/4609 , A61F2002/4687
Abstract: A device for use in total hip arthroplasty surgery including a first guide member having a substantially semi-circular ring having a top surface and a bottom surface, a plurality of first guide legs protruding vertically downward from the lower surface of the semi-circular ring, the first guide legs including a contact area disposed on the open end of the first guide leg; a plurality of holes disposed on the ring, a plurality of protrusions extending vertically upward from a top surface of the ring. The device also includes a second guide member having an arc having an arc of curvature substantially similar to the semi-circular ring, the arc having a top surface and bottom surface, first and second horizontal brackets connecting ends of the arc and being connected thereto at a termination point, a plurality of second guide legs protruding vertically from either the lower surface of the arc, first or second horizontal brackets; and means for connecting the second guide member to the first guide member. The device also includes third and fourth guide members.
Abstract translation: 一种用于全髋关节置换手术的装置，包括具有上表面和底表面的大致半圆环的第一引导构件，从半圆环的下表面垂直向下突出的多个第一引导腿， 所述第一引导腿包括设置在所述第一引导腿的开口端上的接触区域; 设置在所述环上的多个孔，从所述环的顶表面垂直向上延伸的多个突起。 该装置还包括第二引导构件，该第二引导构件具有基本上类似于半圆形环的曲率弧的弧形，该圆弧具有顶表面和底表面，第一和第二水平支架连接圆弧的端部并连接到其上 终止点，从弧的下表面垂直突出的多个第二引导腿，第一或第二水平支架; 以及用于将第二引导构件连接到第一引导构件的装置。 该装置还包括第三和第四引导构件。
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4.发明申请公开(公告)号：US20190008531A1
公开(公告)日：2019-01-10
申请号：US16035049
申请日：2018-07-13
Applicant: INOVA HEALTH SYSTEM
Inventor： Mark THEISS , Jihui LI
Abstract: A method and a device for use in total hip arthroplasty surgery is provided. The device includes a first guide member which includes a body having a top surface and a bottom surface, a plurality of first guide legs protruding from the body, and a plurality of protrusions extending from the body. The plurality of first guide legs include a contact area disposed on the open end of the first guide leg. The device also includes a third guide member which includes a tube, a plate configured to engage with the first guide member, and a plurality of holes disposed on the plate configured to receive the plurality of protrusions of the first guide member to couple the first guide member with the third guide member.
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公开(公告)号：US20170281201A1
公开(公告)日：2017-10-05
申请号：US15630274
申请日：2017-06-22
Applicant: INOVA HEALTH SYSTEM
Inventor： Mark Theiss , Jihui Li
CPC classification number: A61B17/175 , A61B17/1746 , A61B2017/568 , A61F2/30942 , A61F2/4609 , A61F2002/4687
Abstract: A device for use in total hip arthroplasty surgery is provided. The device includes a first guide member which includes a body having a top surface and a bottom surface, a plurality of first guide legs protruding from the body, and a plurality of protrusions extending from the body. The plurality of first guide legs include a contact area disposed on the open end of the first guide leg. The device also includes a third guide member which includes a tube, a plate configured to engage with the first guide member, and a plurality of holes disposed on the plate configured to receive the plurality of protrusions of the first guide member to couple the first guide member with the third guide member.
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Patent Agency Ranking
公开(公告)号：US20170017757A1
公开(公告)日：2017-01-19
申请号：US15249408
申请日：2016-08-27
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications. Provided herein are methods for constructing an ancestral-specific reference genome database.
Abstract translation: 祖先对基因组内每个核苷酸位置发现的主要和次要等位基因具有显着影响。 由于遗传机制，祖先特异性信息包含在基因组内，在祖先的成员中是保守的。 因此，特定祖先的个体更有可能与同一祖先的其他成员共享基因组中的等位基因。 功能上，一组个体内的所有位置上的等位基因的组合将该组定义为具有共同的祖先。 此外，所有位置的等位基因之间的差异的聚集将一个祖先与另一个祖先区分开。 祖先之间的基因组相似性和差异提供了生成对每个祖先特异的参考基因组的机制。 可以使用对祖先特异性的参考基因组来提高全基因组测序，基于DNA的诊断和治疗标记发现的准确性，以及各种真实的基于DNA的应用。 本文提供了构建祖先特异性参考基因组数据库的方法。
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7.发明申请ANCESTRAL-SPECIFIC REFERENCE GENOMES AND USES IN DETERMINING RESPONSE TO AN ACTIVE AGENT 审中-公开管理特定参考基因和用于确定对活性剂的反应公开(公告)号：US20170017754A1
公开(公告)日：2017-01-19
申请号：US15249405
申请日：2016-08-27
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications. Provided herein is a method for determining the likelihood that a patient will respond to a drug therapy by comparing a DNA sequence of the patient's whole genome with the ancestral-specific reference genome, the presence or absence of a clinically relevant genetic marker indicates the likelihood that the patient will or will not respond to the drug therapy.
Abstract translation: 祖先对基因组内每个核苷酸位置发现的主要和次要等位基因具有显着影响。 由于遗传机制，祖先特异性信息包含在基因组内，在祖先的成员中是保守的。 因此，特定祖先的个体更有可能与同一祖先的其他成员共享基因组中的等位基因。 功能上，一组个体内的所有位置上的等位基因的组合将该组定义为具有共同的祖先。 此外，所有位置的等位基因之间的差异的聚集将一个祖先与另一个祖先区分开。 祖先之间的基因组相似性和差异提供了生成对每个祖先特异的参考基因组的机制。 可以使用对祖先特异性的参考基因组来提高全基因组测序，基于DNA的诊断和治疗标记发现的准确性，以及各种真实的基于DNA的应用。 本文提供的方法是通过将患者全基因组的DNA序列与祖先特异性参考基因组进行比较来确定患者将对药物治疗作出反应的可能性，临床相关遗传标记的存在或不存在表明可能性 患者会或不会对药物治疗作出反应。
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8.发明申请公开(公告)号：US20170017753A1
公开(公告)日：2017-01-19
申请号：US15249397
申请日：2016-08-27
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications. Provided herein is a method for determining a prognosis for a genetic disease or disorder comprising the step of comparing a DNA sequence of or derived from the whole genome of a patient with any one or combination of two or more ancestral-specific reference genomes of an ancestral-specific reference genome database described herein to determine the level of severity of the genetic disease or disorder.
Abstract translation: 祖先对基因组内每个核苷酸位置发现的主要和次要等位基因具有显着影响。 由于遗传机制，祖先特异性信息包含在基因组内，在祖先的成员中是保守的。 因此，特定祖先的个体更有可能与同一祖先的其他成员共享基因组中的等位基因。 功能上，一组个体内的所有位置上的等位基因的组合将该组定义为具有共同的祖先。 此外，所有位置的等位基因之间的差异的聚集将一个祖先与另一个祖先区分开。 祖先之间的基因组相似性和差异提供了生成对每个祖先特异的参考基因组的机制。 可以使用对祖先特异性的参考基因组来提高全基因组测序，基于DNA的诊断和治疗标记发现的准确性，以及各种真实的基于DNA的应用。 本文提供了一种用于确定遗传疾病或病症的预后的方法，包括将患者的全部基因组DNA序列或衍生自祖先的两个或多个祖先特异性参考基因组的任一个或组合进行比较的步骤 本文描述的特异性参考基因组数据库以确定遗传性疾病或病症的严重程度。
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公开(公告)号：US20140067280A1
公开(公告)日：2014-03-06
申请号：US13834685
申请日：2013-03-15
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
IPC: G06F19/18
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications.
Abstract translation: 祖先对基因组内每个核苷酸位置发现的主要和次要等位基因具有显着影响。 由于遗传机制，祖先特异性信息包含在基因组内，在祖先的成员中是保守的。 因此，特定祖先的个体更有可能与同一祖先的其他成员共享基因组中的等位基因。 功能上，一组个体内的所有位置上的等位基因的组合将该组定义为具有共同的祖先。 此外，所有位置的等位基因之间的差异的聚集将一个祖先与另一个祖先区分开。 祖先之间的基因组相似性和差异提供了生成对每个祖先特异的参考基因组的机制。 可以使用对祖先特异性的参考基因组来提高全基因组测序，基于DNA的诊断和治疗标记发现的准确性，以及各种真实的基于DNA的应用。
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公开(公告)号：US09639658B2
公开(公告)日：2017-05-02
申请号：US15249397
申请日：2016-08-27
Applicant: Inova Health System
Inventor： Joseph Vockley , John Niederhuber
Abstract: Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry. For this reason, individuals within a specific ancestry are more likely to share alleles in their genomes with other members of the same ancestry. Functionally, the combination of alleles at all positions within a group of individuals defines that group as having a common ancestry. Moreover, the aggregation of differences between alleles at all positions distinguishes one ancestry from another. The genomic similarities and differences between ancestries provides a mechanism to generate reference genomes that are specific for each ancestry. Reference genomes that are specific to an ancestry can be used to increase the accuracy of whole genome sequencing, DNA-based diagnostics and therapeutic marker discovery and in a variety of real-world DNA-based applications. Provided herein is a method for determining a prognosis for a genetic disease or disorder comprising the step of comparing a DNA sequence of or derived from the whole genome of a patient with any one or combination of two or more ancestral-specific reference genomes of an ancestral-specific reference genome database described herein to determine the level of severity of the genetic disease or disorder.
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