公开(公告)号：US20050176115A1

公开(公告)日：2005-08-11

申请号：US10523146

申请日：2003-07-22

申请人： Yoichi Kobayashi ,  Ippei Ono ,  Koichi Hayakawa ,  Ryousuke Mizui ,  Takahiro Ishikawa

发明人： Yoichi Kobayashi ,  Ippei Ono ,  Koichi Hayakawa ,  Ryousuke Mizui ,  Takahiro Ishikawa

IPC分类号： C12P13/12

CPC分类号： C12P13/12

摘要： A practical method for producing methionine is presented. When a substance capable of producing methionine through hydrolysis is used as raw material and converted into methionine by using a biocatalyst, the biocatalyst is repeatedly usable and the accumulation amount of methionine dissolved in the reaction solution is increased, and methionine is obtained in a solid form from the reaction solution. Specifically, the present invention relates to a method for producing methionine comprising the following steps: a first step of converting raw material capable of producing methionine through hydrolysis of 2-amino-4-methylthiobutyronitrile, and 2-amino-4-methylthiobutanamide or the like in an aqueous ammonia solution, into methionine-containing aqueous ammonia solution, with a biocatalyst through hydrolysis, a second step of separating the biocatalyst from the methionine-containing aqueous ammonia solution obtained in the first step, and a third step of distilling ammonia out of the methionine-containing aqueous ammonia solution separated in the second step to deposit and separate crystals of methionine.

摘要翻译： 提出了一种生产甲硫氨酸的实用方法。 当通过水解产生甲硫氨酸的物质被用作原料并且通过使用生物催化剂转化为甲硫氨酸时，生物催化剂是可重复使用的，并且溶解在反应溶液中的甲硫氨酸的积累量增加，以固体形式得到甲硫氨酸 从反应溶液中。 具体地说，本发明涉及一种生产甲硫氨酸的方法，包括以下步骤：通过2-氨基-4-甲硫基丁腈水解生成甲硫氨酸的原料和2-氨基-4-甲硫基丁酰胺等的第一步骤 在含氨基氨水溶液中通过水解生物催化剂，将第一步骤中得到的含有甲硫氨酸的氨水溶液分离生物催化剂的第二步骤，以及将氨蒸馏出来的第三步骤 在第二步中分离出含有甲硫氨酸的氨水溶液以沉积和分离蛋氨酸晶体。