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    Medicinal composition and its use as antidepressive agent
    1.
    发明授权
    Medicinal composition and its use as antidepressive agent 失效
    药用组合物及其用作抗抑郁药

    公开(公告)号：US4189478A

    公开(公告)日：1980-02-19

    申请号：US910782

    申请日：1978-05-30

    申请人： Karl Schmitt ,  Irmgard Hoffmann ,  Werner Fulberth ,  Willi Stammberger

    发明人： Karl Schmitt ,  Irmgard Hoffmann ,  Werner Fulberth ,  Willi Stammberger

    IPC分类号： A61K31/47 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  A61K31/33

    CPC分类号： A61K31/55

    摘要： What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

    摘要翻译： 公开的是含有下式化合物的药物组合物，其可用作抗抑郁剂： 其中可以相同或不同并且表示氢原子或低级烷基或芳烷基的R 1，R 3和R 4以及可以相同或不同的R 2和R 2'表示氢或卤素原子 ，羟基或三氟甲基或低级烷基，烷氧基或芳烷氧基，也可能两个相邻的基团形成亚烷基 - 二氧基，R5表示氢或卤素原子，羟基，三氟甲基或硝基或低级烷基， 烷氧基或芳烷氧基，以及它们与酸（活性物质A）的盐与7-氯-1-甲基-5-苯基-1H-1,5-苯并二氮杂-2,4（3H，5H） - 二酮（活性物质 B），并用作抗抑郁药。

    4-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)-(1,5)diazepine-1H,4H-5,7-diones and medicaments containing same
    4.
    发明授权
    4-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)-(1,5)diazepine-1H,4H-5,7-diones and medicaments containing same 失效
    4-芳基-5,6,7,8-四氢吡唑并（3,4-B） - （1,5）二氮杂-1H，4H-5,7-二酮和含有它们的药物

    公开(公告)号：US4302468A

    公开(公告)日：1981-11-24

    申请号：US177411

    申请日：1980-08-12

    申请人： Gerhard Rackur ,  Irmgard Hoffmann

    发明人： Gerhard Rackur ,  Irmgard Hoffmann

    IPC分类号： A61K31/55 ,  A61P25/20 ,  C07D231/38 ,  C07D231/40 ,  C07D487/04 ,  A61K31/415

    CPC分类号： C07D231/38 ,  C07D231/40 ,  C07D487/04

    摘要： Compound of the general formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and represent hydrogen atoms or alkyl groups with 1-6 C atoms, it also being possible for one of the radicals R.sub.1 and R.sub.2 to be, in each case, a benzyl, trifluoromethyl or phenyl group, R.sub.3 denotes a hydrogen atom, an alkyl group which has 1-6 C atoms and is optionally substituted by an aryl group, an alkoxy group with 1-6 C atoms, a trifluoromethyl group, a dialkylamino group with 2-12 C atoms or a cycloalkyl group with 3-6 C atoms, an alkenyl or alkynyl group with 2-6 C atoms, a cycloalkyl group with 3-6 C atoms or a carbalkoxy group with 2-6 C atoms, R.sub.4 is a hydrogen atom and R.sub.5 can be a phenyl group, a phenyl group which is monosubstituted or disubstituted by methyl Cl, Br, F, nitro, cyano and or trifluoromethyl or a pyridyl group and medicaments containing same.

    摘要翻译： 其中R 1和R 2相同或不同并且表示氢原子或具有1-6个C原子的烷基的通式为“IMAGE”I的化合物，在每一种情况下，基团R 1和R 2之一也可以是 苄基，三氟甲基或苯基，R 3表示氢原子，具有1-6个C原子且任选被芳基取代的烷基，具有1-6个C原子的烷氧基，三氟甲基，二烷基氨基 具有2-12个碳原子或3-6个碳原子的环烷基，2-6个C原子的烯基或炔基，3-6个碳原子的环烷基或2-6个C原子的烷氧基， R4是氢原子，R5可以是苯基，被C1，Br，F，硝基，氰基和/或三氟甲基或吡啶基甲基单取代或二取代的苯基和含有它们的药物。