公开(公告)号：US20150231215A1

公开(公告)日：2015-08-20

申请号：US14534793

申请日：2014-11-06

Applicant: Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LeMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

Inventor： Randolph J. NOELLE ,  Sabrina CEERAZ ,  Isabelle LeMERCIER ,  Elizabeth NOWAK ,  Janet LINES ,  Li WANG ,  Mark SPALLER

IPC: A61K39/00 ,  A61K45/06 ,  C07K7/08

CPC classification number: A61K39/0005 ,  A61K45/06 ,  C07K7/08 ,  C07K16/2827 ,  C07K2317/74 ,  C07K2317/76 ,  G01N33/566 ,  Y02A50/58

Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

Abstract translation: 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。