公开(公告)号：US06734165B2

公开(公告)日：2004-05-11

申请号：US09938746

申请日：2001-08-23

Applicant: Gabriela Chiosis ,  Ivo G. Boneca ,  W. Clark Still

Inventor： Gabriela Chiosis ,  Ivo G. Boneca ,  W. Clark Still

IPC: A61K3816

CPC classification number: A61K31/40 ,  A61K38/14 ,  A61K2300/00

Abstract: The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.

Abstract translation: 本发明涉及一种对万古霉素抗性的革兰氏阳性菌进行再敏化的方法，其中抗细菌量为万古霉素或细菌的细菌壁肽前体中的酰胺键转变为酯键， 万古霉素的同系物和一定量的有效选择性地切割酯键的试剂，从而使万古霉素抗性细菌再敏化。

公开(公告)号：US06953861B2

公开(公告)日：2005-10-11

申请号：US10805624

申请日：2004-03-18

Applicant: Gabriela Chiosis ,  Ivo G. Boneca ,  W. Clark Still

Inventor： Gabriela Chiosis ,  Ivo G. Boneca ,  W. Clark Still

IPC: A61K31/40 ,  A61K38/14 ,  C07D207/08

CPC classification number: A61K31/40 ,  A61K38/14 ,  A61K2300/00

Abstract: The present invention relates to pyrrolidine compounds of the general structure: where n is an integer 1-6 and R is hydrogen or a C1 to C6 straight chain or branched alkyl group, and wherein when n=1, R=CH3 or H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.

Abstract translation: 本发明涉及通式结构的吡咯烷化合物：其中n为整数1-6，R为氢或C 1至C 6直链或支链烷基 并且其中当n = 1时，R = CH 3或H，其可用于对由万古霉素抗性的革兰氏阳性细菌进行再敏化，其中抗性是由酰胺键转化为酯键而导致的 细胞壁的肽前体细菌。