公开(公告)号：US5677342A

公开(公告)日：1997-10-14

申请号：US701144

申请日：1996-08-21

申请人： Michael S. Malamas ,  Iwan Guanwan

发明人： Michael S. Malamas ,  Iwan Guanwan

IPC分类号： A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61P3/00 ,  A61P3/10 ,  C07C45/68 ,  C07C47/575 ,  C07C59/74 ,  C07C69/712

CPC分类号： C07C69/712 ,  C07C45/68 ,  C07C47/575 ,  C07C59/74

摘要： This invention relates to 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids and pharmaceutically acceptable salts thereof according to formula I below, pharmaceutical compositions thereof, a method of treating hyperglycemia due to non-insulin dependent diabetes mellitus, and a method of prevention or treatment of complications associated with diabetes. ##STR1## wherein the group A is selected from the group consisting of 1-naphthyl, 2-naphthyl, optionally substituted with alkyl of from one to six carbon atoms, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkoxy of from one to six carbon atoms; R.sup.1 is hydrogen or alkyl of from one to six carbon atoms; R.sup.2 is selected from hydrogen, fluorine, chlorine, bromine, iodine, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, and hydroxyl; or a pharmaceutically acceptable metal salt thereof.

摘要翻译： 本发明涉及下述通式I的4-甲酰基-2-（萘甲基）苯氧基乙酸及其药学上可接受的盐，其药物组合物，治疗由非胰岛素依赖型糖尿病导致的高血糖症的方法，以及预防或 治疗糖尿病并发症。 其中A组选自任选被1至6个碳原子的烷基取代的1-萘基，2-萘基，氟，氯，溴，碘，三氟甲基，一个烷氧基， 六个碳原子; R1是氢或1-6个碳原子的烷基; R2选自氢，氟，氯，溴，碘，1至6个碳原子的烷基，1至6个碳原子的烷氧基和羟基; 或其药学上可接受的金属盐。