公开(公告)号：US20240124610A1

公开(公告)日：2024-04-18

申请号：US18318232

申请日：2023-05-16

申请人： Nicole Maher ,  Christopher Maher ,  Andrew Nickless ,  Jin Zhang ,  Amy Ly ,  Jace Webster

发明人： Nicole Maher ,  Christopher Maher ,  Andrew Nickless ,  Jin Zhang ,  Amy Ly ,  Jace Webster

IPC分类号： C07K16/32 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/6886

CPC分类号： C07K16/32 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.