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公开(公告)号：US07959914B2
公开(公告)日：2011-06-14
申请号：US10847636
申请日：2004-05-17
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
摘要翻译： 提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。 已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。 本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。 还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。 还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。
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公开(公告)号：US20110262413A1
公开(公告)日：2011-10-27
申请号：US13103347
申请日：2011-05-09
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
摘要翻译： 提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。 已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。 本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。 还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。 还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。
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公开(公告)号：US08679481B2
公开(公告)日：2014-03-25
申请号：US13103347
申请日：2011-05-09
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
摘要翻译： 提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。 已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。 本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。 还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。 还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。
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