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1.发明申请Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof 审中-公开针对人乙酰胆碱酯酶（AChE）的反义寡核苷酸及其应用公开(公告)号：US20090281165A1
公开(公告)日：2009-11-12
申请号：US12287274
申请日：2008-10-07
申请人： Hermona Soreq , Shlomo Saidman , Jackiline Saidman , Tama Evron
发明人： Hermona Soreq , Shlomo Saidman , Jackiline Saidman , Tama Evron
IPC分类号： A61K31/7088 , C07H21/04 , A61P21/00 , A61P21/04 , A61P25/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/53 , C12Y301/01007 , C12N2310/3521
摘要： The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or prevention of neuromuscular disorders, preferably myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
摘要翻译： 本发明涉及靶向人乙酰胆碱酯酶（AChE）的编码区的反义寡核苷酸，其选择性地抑制酶的AChE-R同种型。 反义寡核苷酸旨在用于治疗和/或预防神经肌肉疾病，优选重症肌无力。 此外，它可以穿透血脑屏障（BBB），并破坏中枢神经系统神经元内的AChE-R，同时也可以作为跨越BBB传递分子的载体。
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公开(公告)号：US20060178333A1
公开(公告)日：2006-08-10
申请号：US11346145
申请日：2006-02-01
申请人： Hermona Soreq , Shlomo Saidman , Jackiline Saidman , Tama Evron
发明人： Hermona Soreq , Shlomo Saidman , Jackiline Saidman , Tama Evron
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/53 , C12Y301/01007 , C12N2310/3521
摘要： The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or prevention of neuromuscular disorders, preferably myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
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公开(公告)号：US07074915B2
公开(公告)日：2006-07-11
申请号：US10402016
申请日：2003-03-27
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/53 , C12Y301/01007 , C12N2310/3521
摘要： The invention relates to an antisense oligonucleotide targeted to the coding region of the human acetylcholinesterase (AChE), which selectively suppresses the AChE-R isoform of the enzyme. The antisense oligonucleotide is intended for use in the treatment and/or prevention of neuromuscular disorders, preferably myasthenia gravis. In addition, it can penetrate the blood-brain barrier (BBB) and destroy AChE-R within central nervous system neurons, while also serving as a carrier to transport molecules across the BBB.
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