公开(公告)号：US06723875B1

公开(公告)日：2004-04-20

申请号：US10359121

申请日：2003-02-06

Applicant: Edoardo Pallucca ,  Jacopo Degani ,  Anna Maria Serri ,  Rita Fochi ,  Sonia Gazzetto ,  Claudia Fenoglio ,  Claudio Ornati ,  Mara Migliaccio ,  Silvano Cadamuro ,  Gianni Carvoli

Inventor： Edoardo Pallucca ,  Jacopo Degani ,  Anna Maria Serri ,  Rita Fochi ,  Sonia Gazzetto ,  Claudia Fenoglio ,  Claudio Ornati ,  Mara Migliaccio ,  Silvano Cadamuro ,  Gianni Carvoli

IPC: C07C27300

CPC classification number: C07C273/1809 ,  C07C333/04 ,  C07C333/06 ,  C07C275/04

Abstract: The present invention relates to the preparation of alkyl-ureas, starting from O,S-dimethyl dithiocarbonate, which provides the following steps: A) causing the O,S-dimethyl dithiocarbonate to react with a primary amine of general formula R1NH2 in order to obtain an O-methyl thiocarbamate; B) isomerising the O-methyl thiocarbamate in order to obtain an S-methyl thiocarbamate; C) causing the S-methyl thiocarbamate with a compound of general formula R′R″NH, wherein R′ and R″ may be equal or different one in respect of the other and of R1 and may be H, R2 or R3, in order to obtain one of the alkyl-ureas of formula (4), (5) or (6).

Abstract translation: 本发明涉及从O，S-二甲基二硫代碳酸酯开始制备烷基脲，其提供以下步骤：A）使O，S-二甲基二硫代碳酸酯与通式R 1的伯胺反应， NH 2，以获得O-甲基硫代氨基甲酸酯; B）异构化O-甲基硫代氨基甲酸酯以获得S-甲基硫代氨基甲酸酯; C）用通式R'R''HH的化合物引入S-甲基硫代氨基甲酸酯， 其中R'和R“可以相对于另一个和R 1相同或不同，并且可以是H，R 2或R 3，以获得其中一个烷基 - 脲 式（4），（5）或（6）。