公开(公告)号：US20180162874A1

公开(公告)日：2018-06-14

申请号：US15579115

申请日：2016-06-20

申请人： Gregori J. MORRIELLO ,  Lehua CHANG ,  Ashley FORSTER ,  Yili CHEN ,  Michael P. DWYER ,  Richard BERGER ,  Ming WANG ,  Kausik K. NADA ,  Jaime L. BUNDA ,  William D. SHIPE ,  Merck Sharp & Dohme Corp.

发明人： Gregori J. Morriello ,  Michael P. Dwyer ,  Lehua Chang ,  Yili Chen ,  Ming Wang ,  Ashley Forster ,  Richard Berger ,  Kausik k Nanda ,  Jaime L Bunda ,  William D Shipe

IPC分类号： C07D498/04 ,  C07D473/34 ,  A61P25/18 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D498/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D473/34 ,  C07D487/04

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.