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1.发明授权公开(公告)号：US08178667B2
公开(公告)日：2012-05-15
申请号：US12308929
申请日：2007-06-27
申请人： Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
发明人： Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
IPC分类号： C07D401/10 , C07D401/14 , C07D413/14
CPC分类号： C07D401/10 , C07D215/56 , C07D405/10 , C07D417/10
摘要： The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
摘要翻译： 本发明涉及通式（I）的苄基取代喹诺酮化合物，它是M1受体阳性变构调节剂，可用于治疗涉及M1受体的疾病，例如阿尔茨海默病，疼痛或睡眠障碍 。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及M1受体的疾病中的用途。
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2.发明申请公开(公告)号：US20100009962A1
公开(公告)日：2010-01-14
申请号：US12308929
申请日：2007-06-27
申请人： Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
发明人： Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4709 , C07D413/14 , C07D401/14 , A61K31/497 , A61P25/28
CPC分类号： C07D401/10 , C07D215/56 , C07D405/10 , C07D417/10
摘要： The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
摘要翻译： 本发明涉及通式（I）的苄基取代喹诺酮化合物，它是M1受体阳性变构调节剂，可用于治疗涉及M1受体的疾病，例如阿尔茨海默病，疼痛或睡眠障碍 。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及M1受体的疾病中的用途。
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公开(公告)号：US07345083B2
公开(公告)日：2008-03-18
申请号：US11714352
申请日：2007-03-06
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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公开(公告)号：US07645790B2
公开(公告)日：2010-01-12
申请号：US10586727
申请日：2005-01-26
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。
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公开(公告)号：US20080280966A1
公开(公告)日：2008-11-13
申请号：US10586727
申请日：2005-01-26
IPC分类号： A61K31/403 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂和速激肽抑制剂，特别是物质P的式I的加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性的药物制剂 成分以及化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。
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公开(公告)号：US07217731B2
公开(公告)日：2007-05-15
申请号：US11043213
申请日：2005-01-26
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/44
摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。
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