公开(公告)号：US20160318915A1

公开(公告)日：2016-11-03

申请号：US15209731

申请日：2016-07-13

申请人： Thomas Raymond CAFERRO ,  Zhuoliang CHEN ,  Young Shin CHO ,  Abran Q. COSTALES ,  Julian Roy LEVELL ,  Gang LIU ,  James R. MANNING ,  Martin SENDZIK ,  Cynthia SHAFER ,  Michael David SHULTZ ,  James Clifford SUTTON ,  Yaping WANG ,  Qian ZHAO

发明人： Thomas Raymond CAFERRO ,  Zhuoliang CHEN ,  Young Shin CHO ,  Abran Q. COSTALES ,  Julian Roy LEVELL ,  Gang LIU ,  James R. MANNING ,  Martin SENDZIK ,  Cynthia SHAFER ,  Michael David SHULTZ ,  James Clifford SUTTON ,  Yaping WANG ,  Qian ZHAO

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

摘要翻译： 或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7为本文。 本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。 本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

公开(公告)号：US08957068B2

公开(公告)日：2015-02-17

申请号：US14347481

申请日：2012-09-26

申请人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Young Shin Cho ,  Abran Q. Costales ,  Huangshu Lei ,  Francois Lenoir ,  Julian Roy Levell ,  Gang Liu ,  Mark G. Palermo ,  Keith Bruce Pfister ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  Troy Smith ,  James Clifford Sutton ,  Bakary-Barry Toure ,  Fan Yang ,  Qian Zhao

IPC分类号： C07D413/04 ,  C07D413/14 ,  A61K31/506 ,  C07D487/04 ,  C07D471/04 ,  C07D487/08 ,  C07D417/14 ,  C07D498/10

CPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D498/10 ,  C07D513/04

摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。 本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。 本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。