公开(公告)号：US5070022A

公开(公告)日：1991-12-03

申请号：US288216

申请日：1988-12-22

申请人： David L. Hughes ,  Paul J. Reider ,  Joseph S. Amato ,  James J. Bergan ,  Edward J. J. Grabowski

发明人： David L. Hughes ,  Paul J. Reider ,  Joseph S. Amato ,  James J. Bergan ,  Edward J. J. Grabowski

IPC分类号： C07D215/12 ,  C07D215/18 ,  C12P17/12 ,  C12P41/00

CPC分类号： C12P17/12 ,  C12P41/005

摘要： Disclosed is a process for preparing the R and S enantiomers of a compound of the formula; ##STR1## which comprises; (1) reacting an enzyme with a prochiral diester of the formula ##STR2## where M.sup.1 and M.sup.2 are the same, to produce a chiral monoester of the compound of formula II;(2) treating the chiral monoester product of step (1) with an amine and a trialkyl aluminum compound to produce the R enantiomer of the compound of formula I; or reacting the chiral monoester product of step (1) with an acid activating agent, an amine, and a base to produce the S enantiomer of the compound of formula I.In the alternative the R enantiomer of the compound of formula I may be synthesized by direct enzymatic hydrolysis of the racemic mixture of a compound having the formula ##STR3##