公开(公告)号：US06238873B1

公开(公告)日：2001-05-29

申请号：US09303524

申请日：1999-04-30

申请人： Robert S. Ames ,  Anne Romanic Arnold ,  Jonathan K. Chambers ,  James Joseph Foley ,  Henry M. Sarau ,  Brian R. Stewart

发明人： Robert S. Ames ,  Anne Romanic Arnold ,  Jonathan K. Chambers ,  James Joseph Foley ,  Henry M. Sarau ,  Brian R. Stewart

IPC分类号： G01N3353

CPC分类号： C07K14/705 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/20

摘要： Disclosed are methods for discovering agonists and antagonists of the interaction between UDP-glucose, UDP-galactose, UDP-glucuronic acid, UDP-N-acetyl glucosamine, as well as related UDP sugars, and their cellular receptor, human KIAA0001, which may have utility in the treatment of several human diseases and disorders, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; restenosis; atherosclerosis; diseases characterized by excessive smooth muscle cell proliferation; aneurysms; wound healing; diseases characterized by loss of smooth muscle cells or reduced smooth muscle cell proliferation; stroke; ischemia; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; degenerative diseases, such as neurodegenerative diseases and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others.

摘要翻译： 公开了用于发现UDP-葡萄糖，UDP-半乳糖，UDP-葡糖醛酸，UDP-N-乙酰葡糖胺以及相关的UDP糖和它们的细胞受体之间的相互作用的激动剂和拮抗剂的方法，人类KIAA0001可能具有 包括但不限于：细菌，真菌，原生动物和病毒感染等感染，尤其是HIV-1或HIV-2引起的感染; 疼痛; 癌症; 糖尿病，肥胖; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 再狭窄; 动脉粥样硬化 以过度平滑肌细胞增殖为特征的疾病; 动脉瘤 伤口愈合; 特征在于平滑肌细胞丧失或平滑肌细胞增殖减少的疾病; 行程; 缺血; 溃疡 哮喘; 过敏 良性前列腺肥大; 偏头痛 呕吐 精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，抑郁症，del妄，痴呆和严重智力迟钝; 退行性疾病，如神经退行性疾病和运动障碍，如亨廷顿病或吉尔斯·德拉·图雷特综合征等。