公开(公告)号：US06433144B1

公开(公告)日：2002-08-13

申请号：US09229039

申请日：1999-01-12

Applicant: Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen Feldman ,  Hipolito Hartman

Inventor： Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen Feldman ,  Hipolito Hartman

IPC: C07K1700

CPC classification number: C07K14/56 ,  A61K38/00

Abstract: This invention relates to methods for isolating highly purified mixtures of natural Type I interferon from white blood cells. The invention also relates to highly-purified mixtures of Type I interferon which resemble natural Type I interferon in that the highly purified mixtures of natural Type I interferon includes at least 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to at least 16, and possibly 20 or more molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alphal4-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.

Abstract translation: 本发明涉及从白细胞中分离出高度纯化的天然I型干扰素混合物的方法。 本发明还涉及类似于天然I型干扰素的I型干扰素的高度纯化的混合物，因为天然I型干扰素的高度纯化的混合物包括至少9种亚型，即α-1，α-2，α-5， α-7，α-8，α-10，α-14，α-21和ω，产生至少16种，并且可能有20种或更多种分子物质，包括α-1a，α-1新，α-2a， α-2b，α-2c，α-5，α-5LG，α-7，α-8a，α-8c，α-10a，α-14a，alphal4-b，α14-c，α-14LG， -21a，α-21b，α-21c，ω和ωLG。

公开(公告)号：US06350589B1

公开(公告)日：2002-02-26

申请号：US09224895

申请日：1998-12-31

Applicant: Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen B. Feldman ,  Hipolito Hartman

Inventor： Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen B. Feldman ,  Hipolito Hartman

IPC: C12P100

CPC classification number: C07K14/56 ,  A61K38/00

Abstract: This invention relates to methods for isolating highly-purified mixtures of natural type I interferons from white blood cells. The invention also relates to highly-purified mixtures of natural type I interferons which resemble natural type I interferon in that it includes 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to possibly 20 molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alpha14-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.

Abstract translation: 本发明涉及从白细胞分离天然I型干扰素的高度纯化混合物的方法。 本发明还涉及类似于天然I型干扰素的天然I型干扰素的高度纯化的混合物，因为它包括9种亚型，即α-1，α-2，α-5，α-7，α-8，α -10，α-14，α-21和ω，产生可能20个分子物质，包括α-1a，α-1新，α-2a，α-2b，α-2c，α-5，α-5LG， α-7，α-8a，α-8c，α-10a，α-14a，α14-b，α14-c，α-14LG，α-21a，α-21b，α-21c，ω和ω-LG。