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    Substantially coumarin-free extract of cinnamon and its production method
    3.
    发明授权
    Substantially coumarin-free extract of cinnamon and its production method 有权
    基本上不含香豆素的肉桂提取物及其制备方法

    公开(公告)号：US09131723B2

    公开(公告)日：2015-09-15

    申请号：US13882502

    申请日：2010-11-23

    申请人： James M. Sinambela ,  Veronika Yuliani ,  Deasy Diah Dwi Retno Wulan ,  Raymond R. Tjandrawinata

    发明人： James M. Sinambela ,  Veronika Yuliani ,  Deasy Diah Dwi Retno Wulan ,  Raymond R. Tjandrawinata

    IPC分类号： A61K36/54 ,  A23L1/30

    CPC分类号： A23L1/3002 ,  A23L33/105 ,  A61K36/54 ,  A61K2236/33 ,  A61K2236/39

    摘要： A pharmaceutical composition comprising a substantially coumarin-free extract derived from cinnamon. Its production method including some steps: grinding the raw material, extracting raw material from previous step by maceration using a first solvent to obtain crude extract of Cinnamomum burmanii, fractionating the extracted raw material from previous step through liquid-liquid extraction using a second solvent, wherein the second solvent is immiscible with the first solvent to obtain substantially coumarin-free extract, and optionally drying the substantially coumarin-free extract.The pharmaceutical composition comprising the substantially coumarin-free extract as a single component or in a combination with suitable pharmaceutical excipient(s) to produce a pharmaceutical composition that is safe to be consumed daily and in long-term use.

    摘要翻译： 一种药物组合物，其包含来自肉桂的基本上无香豆素的提取物。 其制备方法包括以下步骤：研磨原料，使用第一溶剂通过浸渍从前一步骤提取原料，得到肉桂粗提物，通过使用第二溶剂的液 - 液萃取将上一步提取的原料分馏， 其中所述第二溶剂与所述第一溶剂不混溶以获得基本上不含香豆素的提取物，以及任选地干燥基本上无香豆素的提取物。 所述药物组合物包含基本上不含香豆素的提取物作为单一组分或与合适的药物赋形剂组合以产生药物组合物，其药物组合物安全地被每天消耗和长期使用。

    SUBSTANTIALLY COUMARIN-FREE EXTRACT OF CINNAMON AND ITS PRODUCTION METHOD
    4.
    发明申请
    SUBSTANTIALLY COUMARIN-FREE EXTRACT OF CINNAMON AND ITS PRODUCTION METHOD 有权
    CINNAMON及其生产方法的实质性无铜提取物

    公开(公告)号：US20130344181A1

    公开(公告)日：2013-12-26

    申请号：US13882502

    申请日：2010-11-23

    申请人： James M. Sinambela ,  Veronika Yuliani ,  Deasy Diah Dwi R.W. ,  Raymond R. Tjandrawinata

    发明人： James M. Sinambela ,  Veronika Yuliani ,  Deasy Diah Dwi R.W. ,  Raymond R. Tjandrawinata

    IPC分类号： A23L1/30 ,  A61K36/54

    CPC分类号： A23L1/3002 ,  A23L33/105 ,  A61K36/54 ,  A61K2236/33 ,  A61K2236/39

    摘要： A pharmaceutical composition comprising a substantially coumarin-free extract derived from cinnamon. Its production method including some steps: grinding the raw material, extracting raw material from previous step by maceration using a first solvent to obtain crude extract of Cinnamomum burmanii, fractionating the extracted raw material from previous step through liquid-liquid extraction using a second solvent, wherein the second solvent is immiscible with the first solvent to obtain substantially coumarin-free extract, and optionally drying the substantially coumarin-free extract.The pharmaceutical composition comprising the substantially coumarin-free extract as a single component or in a combination with suitable pharmaceutical excipient(s) to produce a pharmaceutical composition that is safe to be consumed daily and in long-term use.

    摘要翻译： 一种药物组合物，其包含来自肉桂的基本上无香豆素的提取物。 其制备方法包括以下步骤：研磨原料，使用第一溶剂通过浸渍从前一步骤提取原料，得到肉桂粗提物，通过使用第二溶剂的液 - 液萃取将上一步提取的原料分馏， 其中所述第二溶剂与所述第一溶剂不混溶以获得基本上不含香豆素的提取物，以及任选地干燥基本上无香豆素的提取物。 所述药物组合物包含基本上不含香豆素的提取物作为单一组分或与合适的药物赋形剂组合以产生药物组合物，其药物组合物安全地被每天消耗和长期使用。

    HERBAL EXTRACT AS SENSITIVITY ENHANCER TOWARD INSULIN AND ANTIDIABETES
    5.
    发明申请
    HERBAL EXTRACT AS SENSITIVITY ENHANCER TOWARD INSULIN AND ANTIDIABETES 有权
    草药提取物作为敏感性加强胰岛素和抗生素

    公开(公告)号：US20110177177A1

    公开(公告)日：2011-07-21

    申请号：US13002319

    申请日：2009-08-04

    申请人： Raymond R. Tjandrawinata ,  James M. Sinambela ,  Olivia Mayasari ,  Deasy Diah Dwi R.W. ,  Melissa Puspasari

    发明人： Raymond R. Tjandrawinata ,  James M. Sinambela ,  Olivia Mayasari ,  Deasy Diah Dwi R.W. ,  Melissa Puspasari

    IPC分类号： A61K36/54 ,  A61P3/10

    CPC分类号： A61K36/185 ,  A61K36/54 ,  A61K2300/00

    摘要： A herbal extract composition from Lythraceae and Lauraceae family plants and its usage as insulin resistance reducer, syndrome X normalization, pre-diabetes and type 2 diabetes treatments, particularly as activator in insulin signal pathway, as modulator in glucose transport system, as modulator in adiponectin secretion, and as suppressor in insulin resistance. Representative from Lythraceae family has been selected Lagerstroemia speciosa, and representative from Lauraceae family has been selected Cinnamomum burmannii. Such herbal extract composition work synergistically to strengthen pharmacological effect produced by each extract if they act alone.

    摘要翻译： 作为胰岛素抵抗减少剂，综合征X正常化，前期糖尿病和2型糖尿病治疗，特别是作为胰岛素信号途径中的激活剂，作为葡萄糖转运系统中的调节剂，作为脂连蛋白调节剂的草药提取物组合物 作为胰岛素抵抗的抑制剂。 来自百合科的代表已被选中紫薇属，而从樟科科代表选出樟树。 这种草药提取物组合物协同作用，以增强每种提取物产生的药理作用，如果它们单独作用。